White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation
Citations
Altmetric
Author
Zamani, A; O'Brien, TJ; Kershaw, J; Johnston, LA; Semple, BD; Wright, DKDate
2021-01-07Source Title
Brain Imaging and Behavior: an international journalPublisher
Springer (part of Springer Nature)Affiliation
Medicine and RadiologyBiomedical Engineering
Metadata
Show full item recordDocument Type
Journal ArticleCitations
Zamani, A., O'Brien, T. J., Kershaw, J., Johnston, L. A., Semple, B. D. & Wright, D. K. (2021). White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation. Brain Imaging and Behavior: an international journal, https://doi.org/10.1007/s11682-020-00433-0.Access Status
This item is embargoed and will be available on 2022-01-07Abstract
Pediatric traumatic brain injury (pTBI) is a major community health concern. Due to ongoing maturation, injury to the brain at a young age can have devastating consequences in later life. However, how pTBI affects brain development, including white matter maturation, is still poorly understood. Here, we used advanced diffusion weighted imaging (DWI) to assess chronic white matter changes after experimental pTBI. Mice at post-natal day 21 sustained a TBI using the controlled cortical impact model and magnetic resonance imaging (MRI) was performed at 6 months post-injury using a 4.7 T Bruker scanner. Four diffusion shells with 81 directions and b-values of 1000, 3000, 5000, and 7000s/mm2 were acquired and analyzed using MRtrix3 software. Advanced DWI metrics, including fiber density, fiber cross-section and a combined fiber density and cross-section measure, were investigated together with three track-weighted images (TWI): the average pathlength map, mean curvature and the track density image. These advanced metrics were compared to traditional diffusion tensor imaging (DTI) metrics which indicated that TBI injured mice had reduced fractional anisotropy and increased radial diffusivity in the white matter when compared to age-matched sham controls. Consistent with previous findings, fiber density and TWI metrics appeared to be more sensitive to white matter changes than DTI metrics, revealing widespread reductions in fiber density and TWI metrics in pTBI mice compared to sham controls. These results provide additional support for the use of advanced DWI metrics in assessing white matter degeneration following injury and highlight the chronic outcomes that can follow pTBI.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References