Current questions and possible controversies in autophagy

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Author
Lindqvist, LM; Simon, AK; Baehrecke, EHDate
2015-01-01Source Title
Cell Death DiscoveryPublisher
NATURE PUBLISHING GROUPUniversity of Melbourne Author/s
Lindqvist, LisaAffiliation
Medical Biology (W.E.H.I.)Metadata
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Journal ArticleCitations
Lindqvist, L. M., Simon, A. K. & Baehrecke, E. H. (2015). Current questions and possible controversies in autophagy. CELL DEATH DISCOVERY, 1 (1), https://doi.org/10.1038/cddiscovery.2015.36.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679147Abstract
Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of their roles in autophagy, creating complexities in the interpretation of autophagy (Atg) mutant gene data. Interestingly, this self-eating process is a survival mechanism that can also promote cell death, but when and how autophagy may 'switch' its function is still under debate. Indeed, there are currently many models of how autophagy actually influences cell death. In this review, we highlight some outstanding questions and possible controversies in the autophagy field.
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