Current questions and possible controversies in autophagy
AuthorLindqvist, LM; Simon, AK; Baehrecke, EH
Source TitleCell Death Discovery
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sLindqvist, Lisa
AffiliationMedical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsLindqvist, L. M., Simon, A. K. & Baehrecke, E. H. (2015). Current questions and possible controversies in autophagy. CELL DEATH DISCOVERY, 1 (1), https://doi.org/10.1038/cddiscovery.2015.36.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679147
Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of their roles in autophagy, creating complexities in the interpretation of autophagy (Atg) mutant gene data. Interestingly, this self-eating process is a survival mechanism that can also promote cell death, but when and how autophagy may 'switch' its function is still under debate. Indeed, there are currently many models of how autophagy actually influences cell death. In this review, we highlight some outstanding questions and possible controversies in the autophagy field.
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