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    Current questions and possible controversies in autophagy

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    42
    Author
    Lindqvist, LM; Simon, AK; Baehrecke, EH
    Date
    2015-01-01
    Source Title
    Cell Death Discovery
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Lindqvist, Lisa
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Lindqvist, L. M., Simon, A. K. & Baehrecke, E. H. (2015). Current questions and possible controversies in autophagy. CELL DEATH DISCOVERY, 1 (1), https://doi.org/10.1038/cddiscovery.2015.36.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258935
    DOI
    10.1038/cddiscovery.2015.36
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679147
    Abstract
    Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of their roles in autophagy, creating complexities in the interpretation of autophagy (Atg) mutant gene data. Interestingly, this self-eating process is a survival mechanism that can also promote cell death, but when and how autophagy may 'switch' its function is still under debate. Indeed, there are currently many models of how autophagy actually influences cell death. In this review, we highlight some outstanding questions and possible controversies in the autophagy field.

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