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dc.contributor.authorToh, WH
dc.contributor.authorGleeson, PA
dc.date.accessioned2021-02-03T23:40:33Z
dc.date.available2021-02-03T23:40:33Z
dc.date.issued2016-01-01
dc.identifier.citationToh, W. H. & Gleeson, P. A. (2016). Emerging Insights into the Roles of Membrane Tethers from Analysis of Whole Organisms: The Tip of an Iceberg?. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 4 (FEB), https://doi.org/10.3389/fcell.2016.00012.
dc.identifier.issn2296-634X
dc.identifier.urihttp://hdl.handle.net/11343/258942
dc.description.abstractMembrane tethers have been identified throughout different compartments of the endomembrane system. It is now well established that a number of membrane tethers mediate docking of membrane carriers in anterograde and retrograde transport and in regulating the organization of membrane compartments. Much of our information on membrane tethers have been obtained from the analysis of individual membrane tethers in cultured cells. In the future it will be important to better appreciate the network of interactions mediated by tethers and the potential co-ordination of their collective functions in vivo. There are now a number of studies which have analyzed membrane tethers in tissues and organisms which are providing new insights into the role of this class of membrane protein at the physiological level. Here we review recent advances in the understanding of the function of membrane tethers from knock outs (or knock downs) in whole organisms and from mutations in tethers associated with disease.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEmerging Insights into the Roles of Membrane Tethers from Analysis of Whole Organisms: The Tip of an Iceberg?
dc.typeJournal Article
dc.identifier.doi10.3389/fcell.2016.00012
melbourne.affiliation.departmentBiochemistry and Molecular Biology
melbourne.affiliation.departmentBio21
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.affiliation.facultyAffiliate
melbourne.source.titleFrontiers in Cell and Developmental Biology
melbourne.source.volume4
melbourne.source.issueFEB
melbourne.identifier.nhmrc1082600
melbourne.identifier.arcDP130103207
dc.rights.licenseCC BY
melbourne.elementsid1043625
melbourne.contributor.authorGleeson, Paul
melbourne.contributor.authorToh, Wei Hong
dc.identifier.eissn2296-634X
melbourne.identifier.fundernameidNHMRC, 1082600
melbourne.identifier.fundernameidAustralian Research Council, DP130103207
melbourne.accessrightsOpen Access


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