FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

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    Author
    You, H; Pellegrini, M; Tsuchihara, K; Yamamoto, K; Hacker, G; Erlacher, M; Villunger, A; Mak, TW
    Date
    2006-07-10
    Source Title
    Journal of Experimental Medicine
    Publisher
    ROCKEFELLER UNIV PRESS
    University of Melbourne Author/s
    Pellegrini, Marc
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    You, H., Pellegrini, M., Tsuchihara, K., Yamamoto, K., Hacker, G., Erlacher, M., Villunger, A. & Mak, T. W. (2006). FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. JOURNAL OF EXPERIMENTAL MEDICINE, 203 (7), pp.1657-1663. https://doi.org/10.1084/jem.20060353.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258945
    DOI
    10.1084/jem.20060353
    Abstract
    Puma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, Puma is induced in a p53-dependent manner. However, the transcription factor driving Puma up-regulation in response to p53-independent apoptotic stimuli has yet to be identified. Here, we show that FOXO3a up-regulates Puma expression in response to cytokine or growth factor deprivation. Importantly, dysregulated Akt signaling in lymphoid cells attenuated Puma induction upon cytokine withdrawal. Our results suggest that Puma, together with another BH3 only member, Bim, function as FOXO3a downstream targets to mediate a stress response when PI3K/Akt signaling is down-regulated.

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