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dc.contributor.authorLongley, RJ
dc.contributor.authorHill, AVS
dc.contributor.authorSpencer, AJ
dc.date.accessioned2021-02-03T23:41:51Z
dc.date.available2021-02-03T23:41:51Z
dc.date.issued2015-09-15
dc.identifier.citationLongley, R. J., Hill, A. V. S. & Spencer, A. J. (2015). Malaria vaccines: identifying Plasmodium falciparum liver-stage targets. FRONTIERS IN MICROBIOLOGY, 6 (SEP), https://doi.org/10.3389/fmicb.2015.00965.
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/11343/258946
dc.description.abstractThe development of a highly efficacious and durable vaccine for malaria remains a top priority for global health researchers. Despite the huge rise in recognition of malaria as a global health problem and the concurrent rise in funding over the past 10-15 years, malaria continues to remain a widespread burden. The evidence of increasing resistance to anti-malarial drugs and insecticides is a growing concern. Hence, an efficacious and durable preventative vaccine for malaria is urgently needed. Vaccines are one of the most cost-effective tools and have successfully been used in the prevention and control of many diseases, however, the development of a vaccine for the Plasmodium parasite has proved difficult. Given the early success of whole sporozoite mosquito-bite delivered vaccination strategies, we know that a vaccine for malaria is an achievable goal, with sub-unit vaccines holding great promise as they are simple and cheap to both manufacture and deploy. However a major difficulty in development of sub-unit vaccines lies within choosing the appropriate antigenic target from the 5000 or so genes expressed by the parasite. Given the liver-stage of malaria represents a bottle-neck in the parasite's life cycle, there is widespread agreement that a multi-component sub-unit malaria vaccine should preferably contain a liver-stage target. In this article we review progress in identifying and screening Plasmodium falciparum liver-stage targets for use in a malaria vaccine.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleMalaria vaccines: identifying Plasmodium falciparum liver-stage targets
dc.typeJournal Article
dc.identifier.doi10.3389/fmicb.2015.00965
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFrontiers in Microbiology
melbourne.source.volume6
melbourne.source.issueSEP
dc.rights.licenseCC BY
melbourne.elementsid1046417
melbourne.contributor.authorLongley, Rhea
dc.identifier.eissn1664-302X
melbourne.accessrightsOpen Access


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