Show simple item record

dc.contributor.authorAncelin, M-L
dc.contributor.authorScali, J
dc.contributor.authorNorton, J
dc.contributor.authorRitchie, K
dc.contributor.authorDupuy, A-M
dc.contributor.authorChaudieu, I
dc.contributor.authorRyan, J
dc.date.accessioned2021-02-03T23:46:44Z
dc.date.available2021-02-03T23:46:44Z
dc.date.issued2017-12-01
dc.identifierpii: S2352-2895(16)30034-0
dc.identifier.citationAncelin, M. -L., Scali, J., Norton, J., Ritchie, K., Dupuy, A. -M., Chaudieu, I. & Ryan, J. (2017). The effect of an adverse psychological environment on salivary cortisol levels in the elderly differs by 5-HTTLPR genotype. NEUROBIOLOGY OF STRESS, 7, pp.38-46. https://doi.org/10.1016/j.ynstr.2017.03.002.
dc.identifier.issn2352-2895
dc.identifier.urihttp://hdl.handle.net/11343/258964
dc.description.abstractBACKGROUND: An adverse psychological environment (e.g. stressful events or depression) has been shown to influence basal cortisol levels and cortisol response to stress. This differs depending on the adverse stimuli, but also varies across individuals and may be influenced by genetic predisposition. An insertion/deletion polymorphism in the serotonin transporter gene (5-HTTLPR) is a strong candidate in this regard. OBJECTIVE: To investigate how stressful life events and depression are associated with diurnal cortisol levels in community-dwelling elderly and determine whether this varies according to genetic variability in the 5-HTTLPR. METHODS: This population-based study included 334 subjects aged 65 and older (mean (SD) = 76.5 (6.3)). Diurnal cortisol was measured on two separate days, under quiet (basal) and stressful conditions. The number of recent major stressful events experienced during the past year was assessed from a 12-item validated questionnaire as an index of cumulative recent stressful events. Lifetime trauma was evaluated using the validated Watson's PTSD inventory, which evaluates the most severe traumatic or frightening experience according to DSM criteria. Depression was defined as having a Mini-International Neuropsychiatric Interview (MINI) diagnosis of current major depressive disorder or high levels of depressive symptoms (Center for Epidemiologic Studies-Depression Scale ≥16). 5-HTTLPR genotyping was performed on blood samples. RESULTS: Exposure to stressful life events was associated with lower basal evening cortisol levels overall, and in the participants with the 5-HTTLPR L allele but not the SS genotype. The greatest effects (over 50% decrease, p < 0.001) were observed for the LL participants having experienced multiple recent stressful events or severe lifetime traumas. Participants with the L allele also had higher evening cortisol stress response. Conversely, depression tended to be associated with a 42% higher basal morning cortisol in the SS participants specifically, but did not modify the association between stressful events and cortisol levels. CONCLUSION: An adverse psychological environment is associated with basal cortisol levels and cortisol stress response, but this differs according to 5-HTTLPR genotype.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE INC
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleThe effect of an adverse psychological environment on salivary cortisol levels in the elderly differs by 5-HTTLPR genotype
dc.typeJournal Article
dc.identifier.doi10.1016/j.ynstr.2017.03.002
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleNeurobiology of Stress
melbourne.source.volume7
melbourne.source.pages38-46
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1196771
melbourne.contributor.authorRyan, Joanne
dc.identifier.eissn2352-2895
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record