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dc.contributor.authorWinney, B
dc.contributor.authorBoumertit, A
dc.contributor.authorDay, T
dc.contributor.authorDavison, D
dc.contributor.authorEcheta, C
dc.contributor.authorEvseeva, I
dc.contributor.authorHutnik, K
dc.contributor.authorLeslie, S
dc.contributor.authorNicodemus, K
dc.contributor.authorRoyrvik, EC
dc.contributor.authorTonks, S
dc.contributor.authorYang, X
dc.contributor.authorCheshire, J
dc.contributor.authorLongley, P
dc.contributor.authorMateos, P
dc.contributor.authorGroom, A
dc.contributor.authorRelton, C
dc.contributor.authorBishop, DT
dc.contributor.authorBlack, K
dc.contributor.authorNorthwood, E
dc.contributor.authorParkinson, L
dc.contributor.authorFrayling, TM
dc.contributor.authorSteele, A
dc.contributor.authorSampson, JR
dc.contributor.authorKing, T
dc.contributor.authorDixon, R
dc.contributor.authorMiddleton, D
dc.contributor.authorJennings, B
dc.contributor.authorBowden, R
dc.contributor.authorDonnelly, P
dc.contributor.authorBodmer, W
dc.date.accessioned2021-02-03T23:47:22Z
dc.date.available2021-02-03T23:47:22Z
dc.date.issued2012-02-01
dc.identifierpii: ejhg2011127
dc.identifier.citationWinney, B., Boumertit, A., Day, T., Davison, D., Echeta, C., Evseeva, I., Hutnik, K., Leslie, S., Nicodemus, K., Royrvik, E. C., Tonks, S., Yang, X., Cheshire, J., Longley, P., Mateos, P., Groom, A., Relton, C., Bishop, D. T., Black, K. ,... Bodmer, W. (2012). People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population. EUROPEAN JOURNAL OF HUMAN GENETICS, 20 (2), pp.203-210. https://doi.org/10.1038/ejhg.2011.127.
dc.identifier.issn1018-4813
dc.identifier.urihttp://hdl.handle.net/11343/258967
dc.description.abstractThere is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population. So far, some 4000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3 km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1057 samples demonstrates the value of these samples for investigating a fine-scale population structure within the UK, and shows how this can be enhanced by the use of surnames.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titlePeople of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population
dc.typeJournal Article
dc.identifier.doi10.1038/ejhg.2011.127
melbourne.affiliation.departmentSchool of Mathematics and Statistics
melbourne.affiliation.facultyScience
melbourne.source.titleEuropean Journal of Human Genetics
melbourne.source.volume20
melbourne.source.issue2
melbourne.source.pages203-210
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1047305
melbourne.contributor.authorLeslie, Stephen
dc.identifier.eissn1476-5438
melbourne.accessrightsOpen Access


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