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  • Florey Department of Neuroscience and Mental Health
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    Transcranial magnetic stimulation (TMS) inhibits cortical dendrites

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    53
    Author
    Murphy, SC; Palmer, LM; Nyffeler, T; Mueri, RM; Larkum, ME
    Date
    2016-03-18
    Source Title
    eLife
    Publisher
    ELIFE SCIENCES PUBLICATIONS LTD
    University of Melbourne Author/s
    Palmer, Lucy; Murphy, Sean
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Murphy, S. C., Palmer, L. M., Nyffeler, T., Mueri, R. M. & Larkum, M. E. (2016). Transcranial magnetic stimulation (TMS) inhibits cortical dendrites. ELIFE, 5 (MARCH2016), https://doi.org/10.7554/eLife.13598.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/258997
    DOI
    10.7554/eLife.13598
    NHMRC Grant code
    NHMRC/1085708
    NHMRC/1063533
    Abstract
    One of the leading approaches to non-invasively treat a variety of brain disorders is transcranial magnetic stimulation (TMS). However, despite its clinical prevalence, very little is known about the action of TMS at the cellular level let alone what effect it might have at the subcellular level (e.g. dendrites). Here, we examine the effect of single-pulse TMS on dendritic activity in layer 5 pyramidal neurons of the somatosensory cortex using an optical fiber imaging approach. We find that TMS causes GABAB-mediated inhibition of sensory-evoked dendritic Ca(2+) activity. We conclude that TMS directly activates fibers within the upper cortical layers that leads to the activation of dendrite-targeting inhibitory neurons which in turn suppress dendritic Ca(2+) activity. This result implies a specificity of TMS at the dendritic level that could in principle be exploited for investigating these structures non-invasively.

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