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dc.contributor.authorMurphy, SC
dc.contributor.authorPalmer, LM
dc.contributor.authorNyffeler, T
dc.contributor.authorMueri, RM
dc.contributor.authorLarkum, ME
dc.date.accessioned2021-02-03T23:55:24Z
dc.date.available2021-02-03T23:55:24Z
dc.date.issued2016-03-18
dc.identifier.citationMurphy, S. C., Palmer, L. M., Nyffeler, T., Mueri, R. M. & Larkum, M. E. (2016). Transcranial magnetic stimulation (TMS) inhibits cortical dendrites. ELIFE, 5 (MARCH2016), https://doi.org/10.7554/eLife.13598.
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/11343/258997
dc.description.abstractOne of the leading approaches to non-invasively treat a variety of brain disorders is transcranial magnetic stimulation (TMS). However, despite its clinical prevalence, very little is known about the action of TMS at the cellular level let alone what effect it might have at the subcellular level (e.g. dendrites). Here, we examine the effect of single-pulse TMS on dendritic activity in layer 5 pyramidal neurons of the somatosensory cortex using an optical fiber imaging approach. We find that TMS causes GABAB-mediated inhibition of sensory-evoked dendritic Ca(2+) activity. We conclude that TMS directly activates fibers within the upper cortical layers that leads to the activation of dendrite-targeting inhibitory neurons which in turn suppress dendritic Ca(2+) activity. This result implies a specificity of TMS at the dendritic level that could in principle be exploited for investigating these structures non-invasively.
dc.languageEnglish
dc.publisherELIFE SCIENCES PUBLICATIONS LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleTranscranial magnetic stimulation (TMS) inhibits cortical dendrites
dc.typeJournal Article
dc.identifier.doi10.7554/eLife.13598
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleeLife
melbourne.source.volume5
melbourne.source.issueMARCH2016
melbourne.identifier.nhmrc1085708
melbourne.identifier.nhmrc1063533
dc.rights.licenseCC BY
melbourne.elementsid1053535
melbourne.contributor.authorPalmer, Lucy
melbourne.contributor.authorMurphy, Sean
dc.identifier.eissn2050-084X
melbourne.identifier.fundernameidNHMRC, 1085708
melbourne.identifier.fundernameidNHMRC, 1063533
melbourne.accessrightsOpen Access


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