Nonhuman Primate Ocular Biometry

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Author
Augusteyn, RC; Heilman, BM; Ho, A; Parel, J-MDate
2016-01-01Source Title
Investigative Ophthalmology and Visual SciencePublisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INCUniversity of Melbourne Author/s
Augusteyn, RobertAffiliation
Ophthalmology (Eye & Ear Hospital)Metadata
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Journal ArticleCitations
Augusteyn, R. C., Heilman, B. M., Ho, A. & Parel, J. -M. (2016). Nonhuman Primate Ocular Biometry. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57 (1), pp.105-114. https://doi.org/10.1167/iovs.15-18169.Access Status
Open AccessAbstract
PURPOSE: To examine ocular growth in nonhuman primates (NHPs) from measurements on ex vivo eyes. METHODS: We obtained NHP eyes from animals that had been killed as part of other studies or because of health-related issues. Digital calipers were used to measure the horizontal, vertical, and anteroposterior globe diameters as well as corneal horizontal and vertical diameters of excised globes from 98 hamadryas baboons, 551 cynomolgus monkeys, and 112 rhesus monkeys, at ages ranging from 23 to 360 months. Isolated lens sagittal thickness and equatorial diameter were measured by shadowphotogrammetry. Wet and fixed dry weights were obtained for lenses. RESULTS: Nonhuman primate globe growth continues throughout life, slowing toward an asymptotic maximum. The final globe size scales with negative allometry to adult body size. Corneal growth ceases at around 20 months. Lens diameter increases but thickness decreases with increasing age. Nonhuman primate lens wet and dry weight accumulation is monophasic, continuing throughout life toward asymptotic maxima. The dry/wet weight ratio reaches a maximum of 0.33. CONCLUSIONS: Nonhuman primate ocular globe and lens growth differ in several respects from those in humans. Although age-related losses of lens power and accommodative amplitude are similar, lens growth and properties are different indicating care should be taken in extrapolating NHP observations to the study of human accommodation.
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