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dc.contributor.authorAugusteyn, RC
dc.contributor.authorHeilman, BM
dc.contributor.authorHo, A
dc.contributor.authorParel, J-M
dc.date.accessioned2021-02-04T00:05:10Z
dc.date.available2021-02-04T00:05:10Z
dc.date.issued2016-01-01
dc.identifierpii: 2482658
dc.identifier.citationAugusteyn, R. C., Heilman, B. M., Ho, A. & Parel, J. -M. (2016). Nonhuman Primate Ocular Biometry. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57 (1), pp.105-114. https://doi.org/10.1167/iovs.15-18169.
dc.identifier.issn0146-0404
dc.identifier.urihttp://hdl.handle.net/11343/259027
dc.description.abstractPURPOSE: To examine ocular growth in nonhuman primates (NHPs) from measurements on ex vivo eyes. METHODS: We obtained NHP eyes from animals that had been killed as part of other studies or because of health-related issues. Digital calipers were used to measure the horizontal, vertical, and anteroposterior globe diameters as well as corneal horizontal and vertical diameters of excised globes from 98 hamadryas baboons, 551 cynomolgus monkeys, and 112 rhesus monkeys, at ages ranging from 23 to 360 months. Isolated lens sagittal thickness and equatorial diameter were measured by shadowphotogrammetry. Wet and fixed dry weights were obtained for lenses. RESULTS: Nonhuman primate globe growth continues throughout life, slowing toward an asymptotic maximum. The final globe size scales with negative allometry to adult body size. Corneal growth ceases at around 20 months. Lens diameter increases but thickness decreases with increasing age. Nonhuman primate lens wet and dry weight accumulation is monophasic, continuing throughout life toward asymptotic maxima. The dry/wet weight ratio reaches a maximum of 0.33. CONCLUSIONS: Nonhuman primate ocular globe and lens growth differ in several respects from those in humans. Although age-related losses of lens power and accommodative amplitude are similar, lens growth and properties are different indicating care should be taken in extrapolating NHP observations to the study of human accommodation.
dc.languageEnglish
dc.publisherASSOC RESEARCH VISION OPHTHALMOLOGY INC
dc.titleNonhuman Primate Ocular Biometry
dc.typeJournal Article
dc.identifier.doi10.1167/iovs.15-18169
melbourne.affiliation.departmentOphthalmology (Eye & Ear Hospital)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleInvestigative Ophthalmology and Visual Science
melbourne.source.volume57
melbourne.source.issue1
melbourne.source.pages105-114
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1198103
melbourne.contributor.authorAugusteyn, Robert
dc.identifier.eissn1552-5783
melbourne.accessrightsOpen Access


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