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dc.contributor.authorWilson, D
dc.contributor.authorSeiffge, DJ
dc.contributor.authorTraenka, C
dc.contributor.authorBasir, G
dc.contributor.authorPurrucker, JC
dc.contributor.authorRizos, T
dc.contributor.authorSobowale, OA
dc.contributor.authorSallinen, H
dc.contributor.authorYeh, S-J
dc.contributor.authorWu, TY
dc.contributor.authorFerrigno, M
dc.contributor.authorHouben, R
dc.contributor.authorSchreuder, FHBM
dc.contributor.authorPerry, LA
dc.contributor.authorTanaka, J
dc.contributor.authorBoulanger, M
dc.contributor.authorSalman, RA-S
dc.contributor.authorJaeger, HR
dc.contributor.authorAmbler, G
dc.contributor.authorShakeshaft, C
dc.contributor.authorYakushiji, Y
dc.contributor.authorChoi, PMC
dc.contributor.authorStaals, J
dc.contributor.authorCordonnier, C
dc.contributor.authorJeng, J-S
dc.contributor.authorVeltkamp, R
dc.contributor.authorDowlatshahi, D
dc.contributor.authorEngelter, ST
dc.contributor.authorParry-Jones, AR
dc.contributor.authorMeretoja, A
dc.contributor.authorWerring, DJ
dc.date.accessioned2021-02-04T00:09:18Z
dc.date.available2021-02-04T00:09:18Z
dc.date.issued2017-05-02
dc.identifierpii: WNL.0000000000003886
dc.identifier.citationWilson, D., Seiffge, D. J., Traenka, C., Basir, G., Purrucker, J. C., Rizos, T., Sobowale, O. A., Sallinen, H., Yeh, S. -J., Wu, T. Y., Ferrigno, M., Houben, R., Schreuder, F. H. B. M., Perry, L. A., Tanaka, J., Boulanger, M., Salman, R. A. -S., Jaeger, H. R., Ambler, G. ,... Werring, D. J. (2017). Outcome of intracerebral hemorrhage associated with different oral anticoagulants. NEUROLOGY, 88 (18), pp.1693-1700. https://doi.org/10.1212/WNL.0000000000003886.
dc.identifier.issn0028-3878
dc.identifier.urihttp://hdl.handle.net/11343/259042
dc.description.abstractOBJECTIVE: In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non-vitamin K antagonist oral anticoagulation-related ICH (NOAC-ICH) and vitamin K antagonist-associated ICH (VKA-ICH). METHODS: We compared all-cause mortality within 90 days for NOAC-ICH and VKA-ICH using a Cox proportional hazards model adjusted for age; sex; baseline Glasgow Coma Scale score, ICH location, and log volume; intraventricular hemorrhage volume; and intracranial surgery. We addressed heterogeneity using a shared frailty term. Good functional outcome was defined as discharge modified Rankin Scale score ≤2 and investigated in multivariable logistic regression. ICH volume was measured by ABC/2 or a semiautomated planimetric method. HE was defined as an ICH volume increase >33% or >6 mL from baseline within 72 hours. RESULTS: We included 500 patients (97 NOAC-ICH and 403 VKA-ICH). Median baseline ICH volume was 14.4 mL (interquartile range [IQR] 3.6-38.4) for NOAC-ICH vs 10.6 mL (IQR 4.0-27.9) for VKA-ICH (p = 0.78). We did not find any difference between NOAC-ICH and VKA-ICH for all-cause mortality within 90 days (33% for NOAC-ICH vs 31% for VKA-ICH [p = 0.64]; adjusted Cox hazard ratio (for NOAC-ICH vs VKA-ICH) 0.93 [95% confidence interval (CI) 0.52-1.64] [p = 0.79]), the rate of HE (NOAC-ICH n = 29/48 [40%] vs VKA-ICH n = 93/140 [34%] [p = 0.45]), or functional outcome at hospital discharge (NOAC-ICH vs VKA-ICH odds ratio 0.47; 95% CI 0.18-1.19 [p = 0.11]). CONCLUSIONS: In our international collaborative multicenter pooled analysis, baseline ICH volume, hematoma expansion, 90-day mortality, and functional outcome were similar following NOAC-ICH and VKA-ICH.
dc.languageEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.titleOutcome of intracerebral hemorrhage associated with different oral anticoagulants
dc.typeJournal Article
dc.identifier.doi10.1212/WNL.0000000000003886
melbourne.affiliation.departmentMedicine and Radiology
melbourne.affiliation.facultyCollected Works
melbourne.source.titleNeurology
melbourne.source.volume88
melbourne.source.issue18
melbourne.source.pages1693-1700
dc.rights.licenseCC BY
melbourne.elementsid1197349
melbourne.contributor.authorMeretoja, Atte
melbourne.contributor.authorWu, Teddy
dc.identifier.eissn1526-632X
melbourne.accessrightsOpen Access


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