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dc.contributor.authorWalsh, R
dc.contributor.authorLocarnini, S
dc.date.accessioned2021-02-04T00:14:33Z
dc.date.available2021-02-04T00:14:33Z
dc.date.issued2012-09-01
dc.identifierpii: 201209875
dc.identifier.citationWalsh, R. & Locarnini, S. (2012). Hepatitis B Precore Protein: Pathogenic Potential and Therapeutic Promise. YONSEI MEDICAL JOURNAL, 53 (5), pp.875-885. https://doi.org/10.3349/ymj.2012.53.5.875.
dc.identifier.issn0513-5796
dc.identifier.urihttp://hdl.handle.net/11343/259062
dc.description.abstractHepatitis B virus (HBV), a small and economically packaged double-stranded DNA virus, represents an enormous global health care burden. In spite of an effective vaccine, HBV is endemic in many countries. Chronic hepatitis B (CHB) results in the development of significant clinical outcomes such as liver disease and hepatocellular carcinoma (HCC), which are associated with high mortality rates. HBV is a non-cytopathic virus, with the host's immune response responsible for the associated liver damage. Indeed, HBV appears to be a master of manipulating and modulating the immune response to achieve persistent and chronic infection. The HBV precore protein or hepatitis B e antigen (HBeAg) is a key viral protein involved in these processes, for instance though the down-regulation of the innate immune response. The development of new therapies that target viral proteins, such as HBeAg, which regulates of the immune system, may offer a new wave of potential therapeutics to circumvent progression to CHB and liver disease.
dc.languageEnglish
dc.publisherYONSEI UNIV COLL MEDICINE
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleHepatitis B Precore Protein: Pathogenic Potential and Therapeutic Promise
dc.typeJournal Article
dc.identifier.doi10.3349/ymj.2012.53.5.875
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleYonsei Medical Journal
melbourne.source.volume53
melbourne.source.issue5
melbourne.source.pages875-885
dc.rights.licenseCC BY-NC
melbourne.elementsid1200352
melbourne.contributor.authorLocarnini, Stephen
dc.identifier.eissn1976-2437
melbourne.accessrightsOpen Access


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