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    Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children

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    7
    Author
    Zhou, Y; Hu, L-W; Qian, ZM; Geiger, SD; Parrish, KL; Dharmage, SC; Campbell, B; Roponen, M; Jalava, P; Hirvonen, M-R; ...
    Date
    2017-04-18
    Source Title
    Scientific Reports
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Dharmage, Shyamali; Campbell, Brittany
    Affiliation
    Melbourne School of Population and Global Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Zhou, Y., Hu, L. -W., Qian, Z. M., Geiger, S. D., Parrish, K. L., Dharmage, S. C., Campbell, B., Roponen, M., Jalava, P., Hirvonen, M. -R., Heinrich, J., Zeng, X. -W., Yang, B. -Y., Qin, X. -D., Lee, Y. L. & Dong, G. -H. (2017). Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-01140-5.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259067
    DOI
    10.1038/s41598-017-01140-5
    Abstract
    To evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009-2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents.

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