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dc.contributor.authorZhou, Y
dc.contributor.authorHu, L-W
dc.contributor.authorQian, ZM
dc.contributor.authorGeiger, SD
dc.contributor.authorParrish, KL
dc.contributor.authorDharmage, SC
dc.contributor.authorCampbell, B
dc.contributor.authorRoponen, M
dc.contributor.authorJalava, P
dc.contributor.authorHirvonen, M-R
dc.contributor.authorHeinrich, J
dc.contributor.authorZeng, X-W
dc.contributor.authorYang, B-Y
dc.contributor.authorQin, X-D
dc.contributor.authorLee, YL
dc.contributor.authorDong, G-H
dc.date.accessioned2021-02-04T00:15:53Z
dc.date.available2021-02-04T00:15:53Z
dc.date.issued2017-04-18
dc.identifierpii: 10.1038/s41598-017-01140-5
dc.identifier.citationZhou, Y., Hu, L. -W., Qian, Z. M., Geiger, S. D., Parrish, K. L., Dharmage, S. C., Campbell, B., Roponen, M., Jalava, P., Hirvonen, M. -R., Heinrich, J., Zeng, X. -W., Yang, B. -Y., Qin, X. -D., Lee, Y. L. & Dong, G. -H. (2017). Interaction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-01140-5.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/259067
dc.description.abstractTo evaluate the interactions between polyfluoroalkyl substances (PFASs) and reproductive hormones and associated asthma, a total of 231 asthmatic and 225 non-asthmatic adolescents were selected from northern Taiwan in the Genetic and Biomarkers study for Childhood Asthma from 2009-2010. The interaction between PFASs and reproductive hormones on asthma was analyzed with a two-level binary logistic regression model. The results showed that, among asthmatics, PFASs were positively associated with estradiol levels and negatively associated with testosterone levels. However, only significant association was identified for PFNA and estradiol in control group. After controlling for hormone levels, associations between PFAS exposure and asthma were consistently stronger among children with higher than lower estradiol, with odds ratios (OR) for asthma ranging from 1.25 for PFOS (95% Confidence Interval [CI]: 0.90, 1.72) to 4.01 for PFDA (95% CI: 1.46, 11.06) among boys and 1.25 for PFOS (95% CI: 0.84, 1.86) to 4.16 for PFNA (95% CI: 1.36, 12.73) among girls. Notably, the interactions between estradiol and PFASs were significant for PFOS (p = 0.026) and PFNA (p = 0.043) among girls. However, testosterone significantly attenuated the association between PFOS and asthma across sex. In conclusions, our findings suggested that reproductive hormones amplify the association between PFASs and asthma among adolescents.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleInteraction effects of polyfluoroalkyl substances and sex steroid hormones on asthma among children
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-017-01140-5
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1201812
melbourne.contributor.authorDharmage, Shyamali
melbourne.contributor.authorCampbell, Brittany
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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