Show simple item record

dc.contributor.authorHue, S
dc.contributor.authorAhern, P
dc.contributor.authorBuonocore, S
dc.contributor.authorKullberg, MC
dc.contributor.authorCua, DJ
dc.contributor.authorMcKenzie, BS
dc.contributor.authorPowrie, F
dc.contributor.authorMaloy, KJ
dc.date.accessioned2021-02-04T00:21:15Z
dc.date.available2021-02-04T00:21:15Z
dc.date.issued2006-10-30
dc.identifierpii: jem.20061099
dc.identifier.citationHue, S., Ahern, P., Buonocore, S., Kullberg, M. C., Cua, D. J., McKenzie, B. S., Powrie, F. & Maloy, K. J. (2006). Interleukin-23 drives innate and T cell-mediated intestinal inflammation.. J Exp Med, 203 (11), pp.2473-2483. https://doi.org/10.1084/jem.20061099.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/259090
dc.description.abstractInflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract involving aberrant activation of innate and adaptive immune responses. We have used two complementary models of IBD to examine the roles of interleukin (IL)-12 family cytokines in bacterially induced intestinal inflammation. Our results clearly show that IL-23, but not IL-12, is essential for the induction of chronic intestinal inflammation mediated by innate or adaptive immune mechanisms. Depletion of IL-23 was associated with decreased proinflammatory responses in the intestine but had little impact on systemic T cell inflammatory responses. These results newly identify IL-23 as a driver of innate immune pathology in the intestine and suggest that selective targeting of IL-23 represents an attractive therapeutic approach in human IBD.
dc.languageeng
dc.publisherRockefeller University Press
dc.titleInterleukin-23 drives innate and T cell-mediated intestinal inflammation.
dc.typeJournal Article
dc.identifier.doi10.1084/jem.20061099
melbourne.affiliation.departmentBio21
melbourne.affiliation.facultyCollected Works
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume203
melbourne.source.issue11
melbourne.source.pages2473-2483
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1205337
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118132
melbourne.contributor.authorMcKenzie, Brent
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record