Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
AuthorDeaglio, S; Dwyer, KM; Gao, W; Friedman, D; Usheva, A; Erat, A; Chen, J-F; Enjyoji, K; Linden, J; Oukka, M; ...
Source TitleJournal of Experimental Medicine
PublisherRockefeller University Press
University of Melbourne Author/sDwyer, Karen
AffiliationMedicine (St Vincent's)
Document TypeJournal Article
CitationsDeaglio, S., Dwyer, K. M., Gao, W., Friedman, D., Usheva, A., Erat, A., Chen, J. -F., Enjyoji, K., Linden, J., Oukka, M., Kuchroo, V. K., Strom, T. B. & Robson, S. C. (2007). Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.. J Exp Med, 204 (6), pp.1257-1265. https://doi.org/10.1084/jem.20062512.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118603
The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression. We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5'-nucleotidase distinguishes CD4(+)/CD25(+)/Foxp3(+) T reg cells from other T cells. These ectoenzymes generate pericellular adenosine from extracellular nucleotides. The coordinated expression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops, indicating roles in the inhibitory function of T reg cells. Consequently, T reg cells from Cd39-null mice show impaired suppressive properties in vitro and fail to block allograft rejection in vivo. We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
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