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dc.contributor.authorKlein, A
dc.contributor.authorSchultner, E
dc.contributor.authorLowak, H
dc.contributor.authorSchrader, L
dc.contributor.authorHeinze, J
dc.contributor.authorHolman, L
dc.contributor.authorOettler, J
dc.date.accessioned2021-02-04T00:24:53Z
dc.date.available2021-02-04T00:24:53Z
dc.date.issued2016-03-01
dc.identifierpii: PGENETICS-D-15-03087
dc.identifier.citationKlein, A., Schultner, E., Lowak, H., Schrader, L., Heinze, J., Holman, L. & Oettler, J. (2016). Evolution of Social Insect Polyphenism Facilitated by the Sex Differentiation Cascade. PLOS GENETICS, 12 (3), https://doi.org/10.1371/journal.pgen.1005952.
dc.identifier.issn1553-7404
dc.identifier.urihttp://hdl.handle.net/11343/259103
dc.description.abstractThe major transition to eusociality required the evolution of a switch to canalize development into either a reproductive or a helper, the nature of which is currently unknown. Following predictions from the 'theory of facilitated variation', we identify sex differentiation pathways as promising candidates because of their pre-adaptation to regulating development of complex phenotypes. We show that conserved core genes, including the juvenile hormone-sensitive master sex differentiation gene doublesex (dsx) and a krüppel homolog 2 (kr-h2) with putative regulatory function, exhibit both sex and morph-specific expression across life stages in the ant Cardiocondyla obscurior. We hypothesize that genes in the sex differentiation cascade evolved perception of alternative input signals for caste differentiation (i.e. environmental or genetic cues), and that their inherent switch-like and epistatic behavior facilitated signal transfer to downstream targets, thus allowing them to control differential development into morphological castes.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEvolution of Social Insect Polyphenism Facilitated by the Sex Differentiation Cascade
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pgen.1005952
melbourne.affiliation.departmentSchool of BioSciences
melbourne.affiliation.facultyScience
melbourne.source.titlePLoS Genetics
melbourne.source.volume12
melbourne.source.issue3
dc.rights.licenseCC BY
melbourne.elementsid1207332
melbourne.contributor.authorHolman, Luke
dc.identifier.eissn1553-7404
melbourne.accessrightsOpen Access


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