Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia
AuthorBarzel, B; Weir, JM; Meikle, PJ; Burke, SL; Armitage, JA; Head, GA
Source TitleFrontiers in Physiology
PublisherFRONTIERS MEDIA SA
University of Melbourne Author/sMeikle, Peter
Document TypeJournal Article
CitationsBarzel, B., Weir, J. M., Meikle, P. J., Burke, S. L., Armitage, J. A. & Head, G. A. (2014). Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia. FRONTIERS IN PHYSIOLOGY, 5 (Nov), https://doi.org/10.3389/fphys.2014.00469.
Access StatusOpen Access
Although the association between obesity and hypertension is well-known, the underlying mechanism remains elusive. Previously, we have shown that 3 week fat feeding in rabbits produces greater visceral adiposity, hypertension, tachycardia and elevated renal sympathetic nerve activity (RSNA) compared to rabbits on a normal diet. Because hyperinsulinaemia, hyperleptinemia, and dyslipidaemia are independent cardiovascular risk factors associated with hypertension we compared plasma insulin, leptin, and lipid profiles in male New Zealand White rabbits fed a normal fat diet (NFD 4.3% fat, n = 11) or high fat diet (HFD 13.4% fat, n = 13) at days 1, 2, 3 and weeks 1, 2, 3 of the diet. Plasma concentrations of diacylglyceride (DG), triacylglyceride (TG), ceramide and cholesteryl esters (CE) were obtained after analysis by liquid chromatography mass spectrometry. Plasma insulin and glucose increased within the first 3 days of the diet in HFD rabbits (P < 0.05) and remained elevated at week 1 (P < 0.05). Blood pressure and heart rate (HR) followed a similar pattern. By contrast, in both groups, plasma leptin levels remained unchanged during the first few days (P > 0.05), increasing by week 3 in fat fed animals alone (P < 0.05). Concentrations of total DG, TG, CE, and Ceramide at week 3 did not differ between groups (P > 0.05). Our data show plasma insulin increases rapidly following consumption of a HFD and suggests that it may play a role in the rapid rise of blood pressure. Dyslipidaemia does not appear to contribute to the hypertension in this animal model.
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References