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dc.contributor.authorBoslem, E
dc.contributor.authorMeikle, PJ
dc.contributor.authorBiden, TJ
dc.date.accessioned2021-02-04T00:26:59Z
dc.date.available2021-02-04T00:26:59Z
dc.date.issued2012-05-01
dc.identifierpii: 20102
dc.identifier.citationBoslem, E., Meikle, P. J. & Biden, T. J. (2012). Roles of ceramide and sphingolipids in pancreatic beta-cell function and dysfunction. ISLETS, 4 (3), pp.177-187. https://doi.org/10.4161/isl.20102.
dc.identifier.issn1938-2014
dc.identifier.urihttp://hdl.handle.net/11343/259110
dc.description.abstractRecent technical advances have re-invigorated the study of sphingolipid metabolism in general, and helped to highlight the varied and important roles that sphingolipids play in pancreatic β-cells. Sphingolipid metabolites such as ceramide, glycosphingolipids, sphingosine 1-phosphate and gangliosides modulate many β-cell signaling pathways and processes implicated in β-cell diabetic disease such as apoptosis, β-cell cytokine secretion, ER-to-golgi vesicular trafficking, islet autoimmunity and insulin gene expression. They are particularly relevant to lipotoxicity. Moreover, the de novo synthesis of sphingolipids occurs on many subcellular membranes, in parallel to secretory vesicle formation, traffic and granule maturation events. Indeed, the composition of the plasma membrane, determined by the activity of neutral sphingomyelinases, affects β-cell excitability and potentially insulin exocytosis while another glycosphingolipid, sulfatide, determines the stability of insulin crystals in granules. Most importantly, sphingolipid metabolism on internal membranes is also strongly implicated in regulating β-cell apoptosis.
dc.languageEnglish
dc.publisherTAYLOR & FRANCIS INC
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleRoles of ceramide and sphingolipids in pancreatic beta-cell function and dysfunction
dc.typeJournal Article
dc.identifier.doi10.4161/isl.20102
melbourne.affiliation.departmentBio21
melbourne.affiliation.facultyAffiliate
melbourne.source.titleIslets
melbourne.source.volume4
melbourne.source.issue3
melbourne.source.pages177-187
dc.rights.licenseCC BY-NC
melbourne.elementsid1208068
melbourne.contributor.authorMeikle, Peter
dc.identifier.eissn1938-2022
melbourne.accessrightsOpen Access


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