Androgen signaling negatively controls group 2 innate lymphoid cells

Download
Author
Laffont, S; Blanquart, E; Savignac, M; Cenac, C; Laverny, G; Metzger, D; Girard, J-P; Belz, GT; Pelletier, L; Seillet, C; ...Date
2017-06-01Source Title
Journal of Experimental MedicinePublisher
ROCKEFELLER UNIV PRESSAffiliation
Medical Biology (W.E.H.I.)Metadata
Show full item recordDocument Type
Journal ArticleCitations
Laffont, S., Blanquart, E., Savignac, M., Cenac, C., Laverny, G., Metzger, D., Girard, J. -P., Belz, G. T., Pelletier, L., Seillet, C. & Guery, J. -C. (2017). Androgen signaling negatively controls group 2 innate lymphoid cells. JOURNAL OF EXPERIMENTAL MEDICINE, 214 (6), pp.1581-1592. https://doi.org/10.1084/jem.20161807.Access Status
Open AccessAbstract
Prevalence of asthma is higher in women than in men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) are key regulators of type 2 inflammatory responses. Here, we show that ILC2 development is greatly influenced by male sex hormones. Male mice have reduced numbers of ILC2 progenitors (ILC2Ps) and mature ILC2s in peripheral tissues compared with females. In consequence, males exhibit reduced susceptibility to allergic airway inflammation in response to environmental allergens and less severe IL-33-driven lung inflammation, correlating with an impaired expansion of lung ILC2s. Importantly, orchiectomy, but not ovariectomy, abolishes the sex differences in ILC2 development and restores IL-33-mediated lung inflammation. ILC2Ps express the androgen receptor (AR), and AR signaling inhibits their differentiation into mature ILC2s. Finally, we show that hematopoietic AR expression limits IL-33-driven lung inflammation through a cell-intrinsic inhibition of ILC2 expansion. Thus, androgens play a crucial protective role in type 2 airway inflammation by negatively regulating ILC2 homeostasis, thereby limiting their capacity to expand locally in response to IL-33.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References
Collections
- Minerva Elements Records [52609]
- Medical Biology - Research Publications [1412]