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dc.contributor.authorLaffont, S
dc.contributor.authorBlanquart, E
dc.contributor.authorSavignac, M
dc.contributor.authorCenac, C
dc.contributor.authorLaverny, G
dc.contributor.authorMetzger, D
dc.contributor.authorGirard, J-P
dc.contributor.authorBelz, GT
dc.contributor.authorPelletier, L
dc.contributor.authorSeillet, C
dc.contributor.authorGuery, J-C
dc.date.accessioned2021-02-04T00:28:22Z
dc.date.available2021-02-04T00:28:22Z
dc.date.issued2017-06-01
dc.identifierpii: jem.20161807
dc.identifier.citationLaffont, S., Blanquart, E., Savignac, M., Cenac, C., Laverny, G., Metzger, D., Girard, J. -P., Belz, G. T., Pelletier, L., Seillet, C. & Guery, J. -C. (2017). Androgen signaling negatively controls group 2 innate lymphoid cells. JOURNAL OF EXPERIMENTAL MEDICINE, 214 (6), pp.1581-1592. https://doi.org/10.1084/jem.20161807.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/259116
dc.description.abstractPrevalence of asthma is higher in women than in men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) are key regulators of type 2 inflammatory responses. Here, we show that ILC2 development is greatly influenced by male sex hormones. Male mice have reduced numbers of ILC2 progenitors (ILC2Ps) and mature ILC2s in peripheral tissues compared with females. In consequence, males exhibit reduced susceptibility to allergic airway inflammation in response to environmental allergens and less severe IL-33-driven lung inflammation, correlating with an impaired expansion of lung ILC2s. Importantly, orchiectomy, but not ovariectomy, abolishes the sex differences in ILC2 development and restores IL-33-mediated lung inflammation. ILC2Ps express the androgen receptor (AR), and AR signaling inhibits their differentiation into mature ILC2s. Finally, we show that hematopoietic AR expression limits IL-33-driven lung inflammation through a cell-intrinsic inhibition of ILC2 expansion. Thus, androgens play a crucial protective role in type 2 airway inflammation by negatively regulating ILC2 homeostasis, thereby limiting their capacity to expand locally in response to IL-33.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleAndrogen signaling negatively controls group 2 innate lymphoid cells
dc.typeJournal Article
dc.identifier.doi10.1084/jem.20161807
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume214
melbourne.source.issue6
melbourne.source.pages1581-1592
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1208346
melbourne.contributor.authorBelz, Gabrielle
melbourne.contributor.authorSeillet, Cyril
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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