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    Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.

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    223
    Author
    Schlissel, MS; Corcoran, LM; Baltimore, D
    Date
    1991-03-01
    Source Title
    Journal of Experimental Medicine
    Publisher
    Rockefeller University Press
    University of Melbourne Author/s
    Corcoran, Lynn
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Schlissel, M. S., Corcoran, L. M. & Baltimore, D. (1991). Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.. J Exp Med, 173 (3), pp.711-720. https://doi.org/10.1084/jem.173.3.711.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259117
    DOI
    10.1084/jem.173.3.711
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118835
    Abstract
    Virus-transformed pre-B cells undergo ordered immunoglobulin (Ig) gene rearrangements during culture. We devised a series of highly sensitive polymerase chain reaction assays for Ig gene rearrangement and unrearranged Ig gene segment transcription to study both the possible relationship between these processes in cultured pre-B cells and the role played by heavy (H) chain (mu) protein in regulating gene rearrangement. Our analysis of pre-B cell cultures representing various stages of maturity revealed that transcription of each germline Ig locus precedes or is coincident with its rearrangement. Cell lines containing one functional rearranged H chain allele, however, continue to transcribe and to rearrange the allelic, unrearranged H chain locus. These cell lines appear to initiate but not terminate rearrangement events and therefore provide information about the requirements for activating rearrangement but not about allelic exclusion mechanisms.

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