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    Intravenous Immunoglobulin Protects Against Severe Pandemic Influenza Infection

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    Author
    Rockman, S; Lowther, S; Camuglia, S; Vandenberg, K; Taylor, S; Fabri, L; Miescher, S; Pearse, M; Middleton, D; Kent, SJ; ...
    Date
    2017-05-01
    Source Title
    EBioMedicine
    Publisher
    ELSEVIER SCIENCE BV
    University of Melbourne Author/s
    Kent, Stephen; Fabri, Louis; Rockman, Steven
    Affiliation
    Microbiology and Immunology
    Bio21
    Metadata
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    Document Type
    Journal Article
    Citations
    Rockman, S., Lowther, S., Camuglia, S., Vandenberg, K., Taylor, S., Fabri, L., Miescher, S., Pearse, M., Middleton, D., Kent, S. J. & Maher, D. (2017). Intravenous Immunoglobulin Protects Against Severe Pandemic Influenza Infection. EBIOMEDICINE, 19, pp.119-127. https://doi.org/10.1016/j.ebiom.2017.04.010.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259144
    DOI
    10.1016/j.ebiom.2017.04.010
    Abstract
    Influenza is a highly contagious, acute, febrile respiratory infection that can have fatal consequences particularly in individuals with chronic illnesses. Sporadic reports suggest that intravenous immunoglobulin (IVIg) may be efficacious in the influenza setting. We investigated the potential of human IVIg to ameliorate influenza infection in ferrets exposed to either the pandemic H1N1/09 virus (pH1N1) or highly pathogenic avian influenza (H5N1). IVIg administered at the time of influenza virus exposure led to a significant reduction in lung viral load following pH1N1 challenge. In the lethal H5N1 model, the majority of animals given IVIg survived challenge in a dose dependent manner. Protection was also afforded by purified F(ab')2 but not Fc fragments derived from IVIg, supporting a specific antibody-mediated mechanism of protection. We conclude that pre-pandemic IVIg can modulate serious influenza infection-associated mortality and morbidity. IVIg could be useful prophylactically in the event of a pandemic to protect vulnerable population groups and in the critical care setting as a first stage intervention.

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