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dc.contributor.authorSutherland, RM
dc.contributor.authorLondrigan, SL
dc.contributor.authorBrady, JL
dc.contributor.authorCarrington, EM
dc.contributor.authorMarchingo, JM
dc.contributor.authorHeinzel, S
dc.contributor.authorHodgkin, PD
dc.contributor.authorGraham, KL
dc.contributor.authorKay, TW
dc.contributor.authorZhan, Y
dc.contributor.authorLew, AM
dc.date.accessioned2021-02-04T00:36:46Z
dc.date.available2021-02-04T00:36:46Z
dc.date.issued2017-04-12
dc.identifierpii: ncomms14809
dc.identifier.citationSutherland, R. M., Londrigan, S. L., Brady, J. L., Carrington, E. M., Marchingo, J. M., Heinzel, S., Hodgkin, P. D., Graham, K. L., Kay, T. W., Zhan, Y. & Lew, A. M. (2017). Cognate antigen engagement on parenchymal cells stimulates CD8(+) T cell proliferation in situ. NATURE COMMUNICATIONS, 8 (1), https://doi.org/10.1038/ncomms14809.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/259146
dc.description.abstractT-cell responses are initiated upon cognate presentation by professional antigen presenting cells in lymphoid tissue. T cells then migrate to inflamed tissues, but further T-cell stimulation in these parenchymal target sites is not well understood. Here we show that T-cell expansion within inflamed tissues is a distinct phase that is neither a classical primary nor classical secondary response. This response, which we term 'the mezzanine response', commences within days after initial antigen encounter, unlike the secondary response that usually occurs weeks after priming. A further distinction of this response is that T-cell proliferation is driven by parenchymal cell antigen presentation, without requiring professional antigen presenting cells, but with increased dependence on IL-2. The mezzanine response might, therefore, be a new target for inhibiting T-cell responses in allograft rejection and autoimmunity or for enhancing T-cell responses in the context of microbial or tumour immunity.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCognate antigen engagement on parenchymal cells stimulates CD8(+) T cell proliferation in situ
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms14809
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleNature Communications
melbourne.source.volume8
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1201650
melbourne.contributor.authorGraham, Kate
melbourne.contributor.authorLondrigan, Sarah
melbourne.contributor.authorCarrington, Emma
melbourne.contributor.authorMarchingo, Julia
melbourne.contributor.authorHeinzel, Susanne
melbourne.contributor.authorLew, Andrew
melbourne.contributor.authorKay, Thomas
melbourne.contributor.authorSutherland, Robyn
melbourne.contributor.authorHodgkin, Philip
melbourne.contributor.authorBrady, Jamie
melbourne.contributor.authorZhan, Yifan
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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