Use of anticoagulants and antiplatelet in patients with chronic lymphocytic leukaemia treated with single-agent ibrutinib

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Jones, JA; Hillmen, P; Coutre, S; Tam, C; Furman, RR; Barr, PM; Schuster, SJ; Kipps, TJ; Flinn, IW; Jaeger, U; ...Date
2017-07-01Source Title
British Journal of HaematologyPublisher
WILEYUniversity of Melbourne Author/s
Tam, ConstantineAffiliation
Medicine and RadiologyMetadata
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Jones, J. A., Hillmen, P., Coutre, S., Tam, C., Furman, R. R., Barr, P. M., Schuster, S. J., Kipps, T. J., Flinn, I. W., Jaeger, U., Burger, J. A., Cheng, M., Ninomoto, J., James, D. F., Byrd, J. C. & O'Brien, S. M. (2017). Use of anticoagulants and antiplatelet in patients with chronic lymphocytic leukaemia treated with single-agent ibrutinib. BRITISH JOURNAL OF HAEMATOLOGY, 178 (2), pp.286-291. https://doi.org/10.1111/bjh.14660.Access Status
Open AccessAbstract
Bleeding events have been observed among a subgroup of chronic lymphocytic leukaemia (CLL) patients treated with ibrutinib. We analysed data from two studies of single-agent ibrutinib to better characterize bleeding events and pattern of anticoagulation and antiplatelet use. Among 327 ibrutinib-treated patients, concomitant anticoagulation (11%) or antiplatelet use (34%) was common, but major bleeding was infrequent (2%). Bleeding events were primarily grade 1, and infrequently (1%) led to discontinuation. Among 175 patients receiving concomitant anticoagulant or antiplatelet agents, 5 had major bleeding events (3%). These events were typically observed in conjunction with other factors, such as coexisting medical conditions and/or concurrent medications.
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