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    Use of anticoagulants and antiplatelet in patients with chronic lymphocytic leukaemia treated with single-agent ibrutinib

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    Author
    Jones, JA; Hillmen, P; Coutre, S; Tam, C; Furman, RR; Barr, PM; Schuster, SJ; Kipps, TJ; Flinn, IW; Jaeger, U; ...
    Date
    2017-07-01
    Source Title
    British Journal of Haematology
    Publisher
    WILEY
    University of Melbourne Author/s
    Tam, Constantine
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Jones, J. A., Hillmen, P., Coutre, S., Tam, C., Furman, R. R., Barr, P. M., Schuster, S. J., Kipps, T. J., Flinn, I. W., Jaeger, U., Burger, J. A., Cheng, M., Ninomoto, J., James, D. F., Byrd, J. C. & O'Brien, S. M. (2017). Use of anticoagulants and antiplatelet in patients with chronic lymphocytic leukaemia treated with single-agent ibrutinib. BRITISH JOURNAL OF HAEMATOLOGY, 178 (2), pp.286-291. https://doi.org/10.1111/bjh.14660.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259160
    DOI
    10.1111/bjh.14660
    Abstract
    Bleeding events have been observed among a subgroup of chronic lymphocytic leukaemia (CLL) patients treated with ibrutinib. We analysed data from two studies of single-agent ibrutinib to better characterize bleeding events and pattern of anticoagulation and antiplatelet use. Among 327 ibrutinib-treated patients, concomitant anticoagulation (11%) or antiplatelet use (34%) was common, but major bleeding was infrequent (2%). Bleeding events were primarily grade 1, and infrequently (1%) led to discontinuation. Among 175 patients receiving concomitant anticoagulant or antiplatelet agents, 5 had major bleeding events (3%). These events were typically observed in conjunction with other factors, such as coexisting medical conditions and/or concurrent medications.

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