Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever among Rural and Urban Populations of Northern Vietnam

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    Author
    Nguyen, VT; Le, TH; Nguyen, THT; Tran, KT; Tran, TKH; Tran, MH; Fox, A; Nguyen, VK; van Doorn, HR; Wertheim, HFL; ...
    Date
    2017-01-01
    Source Title
    American Journal of Tropical Medicine and Hygiene
    Publisher
    AMER SOC TROP MED & HYGIENE
    University of Melbourne Author/s
    Marsh, Annette; Fox (marsh), Annette
    Affiliation
    Infectious Diseases
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Nguyen, V. T., Le, T. H., Nguyen, T. H. T., Tran, K. T., Tran, T. K. H., Tran, M. H., Fox, A., Nguyen, V. K., van Doorn, H. R., Wertheim, H. F. L., Bryant, J. E. & Nadjm, B. (2017). Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever among Rural and Urban Populations of Northern Vietnam. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 96 (5), pp.1084-1087. https://doi.org/10.4269/ajtmh.16-0399.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259174
    DOI
    10.4269/ajtmh.16-0399
    Abstract
    AbstractRickettsial infections are recognized as important causes of fever throughout southeast Asia. Herein, we determined the seroprevalence to rickettsioses within rural and urban populations of northern Vietnam. Prevalence of individuals with evidence of prior rickettsial infections (IgG positive) was surprisingly low, with 9.14% (83/908) testing positive to the three major rickettsial serogroups thought to circulate in the region. Prevalence of typhus group rickettsiae (TG)-specific antibodies (6.5%, 58/908) was significantly greater than scrub typhus group orientiae (STG)- or spotted fever group rickettsiae (SFG)-specific antibodies (P < 0.05). The majority of TG seropositives were observed among urban rather than rural residents (P < 0.05). In contrast, overall antibody prevalence to STG and SFG were both very low (1.1%, 10/908 for STG; 1.7%, 15/908 for SFG), with no significant differences between rural and urban residents. These results provide data on baseline population characteristics that may help inform development of Rickettsia serological testing criteria in future clinical studies.

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