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dc.contributor.authorSmolkina, M
dc.contributor.authorMorley, KI
dc.contributor.authorRijsdijk, F
dc.contributor.authorAgrawal, A
dc.contributor.authorBergin, JE
dc.contributor.authorNelson, EC
dc.contributor.authorStatham, D
dc.contributor.authorMartin, NG
dc.contributor.authorLynskey, MT
dc.date.accessioned2021-02-04T00:55:32Z
dc.date.available2021-02-04T00:55:32Z
dc.date.issued2017-07-01
dc.identifierpii: 10.1007/s10519-017-9848-0
dc.identifier.citationSmolkina, M., Morley, K. I., Rijsdijk, F., Agrawal, A., Bergin, J. E., Nelson, E. C., Statham, D., Martin, N. G. & Lynskey, M. T. (2017). Cannabis and Depression: A Twin Model Approach to Co-morbidity. BEHAVIOR GENETICS, 47 (4), pp.394-404. https://doi.org/10.1007/s10519-017-9848-0.
dc.identifier.issn0001-8244
dc.identifier.urihttp://hdl.handle.net/11343/259224
dc.description.abstractCannabis use disorder (CUD) co-occurs with major depressive disorder (MDD) more frequently than would be expected by chance. However, studies to date have not produced a clear understanding of the mechanisms underlying this co-morbidity. Genetically informative studies can add valuable insight to this problem, as they allow the evaluation of competing models of co-morbidity. This study uses data from the Australian Twin Registry to compare 13 co-morbidity twin models initially proposed by Neale and Kendler (Am J Hum Genet 57:935-953, 1995). The analysis sample comprised 2410 male and female monozygotic and dizygotic twins (average age 32) who were assessed on CUD and MDD using the SSAGA-OZ interview. Data were analyzed in OpenMx. Of the 13 different co-morbidity models, two fit equally well: CUD causes MDD and Random Multiformity of CUD. Both fit substantially better than the Correlated Liabilities model. Although the current study cannot differentiate between them statistically, these models, in combination, suggest that CUD risk factors may causally influence the risk to develop MDD, but only when risk for CUD is high.
dc.languageEnglish
dc.publisherSPRINGER
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCannabis and Depression: A Twin Model Approach to Co-morbidity
dc.typeJournal Article
dc.identifier.doi10.1007/s10519-017-9848-0
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleBehavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
melbourne.source.volume47
melbourne.source.issue4
melbourne.source.pages394-404
melbourne.identifier.nhmrc628911
dc.rights.licenseCC BY
melbourne.elementsid1205830
melbourne.contributor.authorMorley, Katherine
dc.identifier.eissn1573-3297
melbourne.identifier.fundernameidNHMRC, 628911
melbourne.accessrightsOpen Access


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