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    Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain

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    Author
    Meikle, P; Low, H; Churchill, MJ; Bukrinsky, M; Sviridov, D
    Date
    2016-03-01
    Source Title
    Data in Brief
    Publisher
    ELSEVIER SCIENCE BV
    University of Melbourne Author/s
    Meikle, Peter
    Affiliation
    Bio21
    Metadata
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    Document Type
    Journal Article
    Citations
    Meikle, P., Low, H., Churchill, M. J., Bukrinsky, M. & Sviridov, D. (2016). Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain. DATA IN BRIEF, 6, pp.168-175. https://doi.org/10.1016/j.dib.2015.11.067.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259227
    DOI
    10.1016/j.dib.2015.11.067
    Abstract
    Previous in vitro and in vivo studies demonstrated that HIV protein nef plays a key role in impairing cellular and systemic cholesterol metabolism in HIV disease, but clinical support for these findings is lacking. Here we present the data of comparative lipidomic analysis (330 lipid species) of plasma samples from HIV-negative subjects, patients infected with WT HIV-1 strain and patients infected with nef-deficient strain of HIV-1. We determine which effects of HIV on plasma lipidome are explained by the presence of nef. The data can be used to evaluate cardiovascular risk in HIV disease and to assess the role of nef in HIV-induced disturbances in systemic lipid metabolism. The full impact of nef deficiency on lipid and lipoprotein metabolism in HIV-infected patients is presented in the accompanying study "Lipid Metabolism in Patients Infected with Nef-deficient HIV-1 Strain" [1].

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