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    Gene Expression Noise Enhances Robust Organization of the Early Mammalian Blastocyst.

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    13
    Author
    Holmes, WR; Reyes de Mochel, NS; Wang, Q; Du, H; Peng, T; Chiang, M; Cinquin, O; Cho, K; Nie, Q
    Date
    2017-01
    Source Title
    PLoS Computational Biology
    Publisher
    Public Library of Science (PLoS)
    University of Melbourne Author/s
    HOLMES, WILLIAM
    Affiliation
    School of Mathematics and Statistics
    Metadata
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    Document Type
    Journal Article
    Citations
    Holmes, W. R., Reyes de Mochel, N. S., Wang, Q., Du, H., Peng, T., Chiang, M., Cinquin, O., Cho, K. & Nie, Q. (2017). Gene Expression Noise Enhances Robust Organization of the Early Mammalian Blastocyst.. PLoS Comput Biol, 13 (1), pp.e1005320-. https://doi.org/10.1371/journal.pcbi.1005320.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259233
    DOI
    10.1371/journal.pcbi.1005320
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293272
    Abstract
    A critical event in mammalian embryo development is construction of an inner cell mass surrounded by a trophoectoderm (a shell of cells that later form extraembryonic structures). We utilize multi-scale, stochastic modeling to investigate the design principles responsible for robust establishment of these structures. This investigation makes three predictions, each supported by our quantitative imaging. First, stochasticity in the expression of critical genes promotes cell plasticity and has a critical role in accurately organizing the developing mouse blastocyst. Second, asymmetry in the levels of noise variation (expression fluctuation) of Cdx2 and Oct4 provides a means to gain the benefits of noise-mediated plasticity while ameliorating the potentially detrimental effects of stochasticity. Finally, by controlling the timing and pace of cell fate specification, the embryo temporally modulates plasticity and creates a time window during which each cell can continually read its environment and adjusts its fate. These results suggest noise has a crucial role in maintaining cellular plasticity and organizing the blastocyst.

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