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    Elevated fasting insulin predicts the future incidence of metabolic syndrome: a 5-year follow-up study

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    Author
    Sung, K-CC; Seo, M-HH; Rhee, E-JJ; Wilson, AM
    Date
    2011-11-30
    Source Title
    Cardiovascular Diabetology
    Publisher
    BIOMED CENTRAL LTD
    University of Melbourne Author/s
    Wilson, Andrew
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Sung, K. -C. C., Seo, M. -H. H., Rhee, E. -J. J. & Wilson, A. M. (2011). Elevated fasting insulin predicts the future incidence of metabolic syndrome: a 5-year follow-up study. CARDIOVASCULAR DIABETOLOGY, 10 (1), https://doi.org/10.1186/1475-2840-10-108.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259235
    DOI
    10.1186/1475-2840-10-108
    Abstract
    BACKGROUND: There is controversy about the specific pathophysiology of metabolic syndrome (MS) but several authors have argued that hyperinsulinemia is a key feature of the cluster. We aimed to assess whether the baseline insulin levels could predict the development of MS in a well characterised cohort of otherwise healthy adults who were followed over a five year period. METHODS: We identified 2, 350 Koreans subjects who did not have MS in 2003 and who were followed up in 2008. The subjects were divided into 4 groups according to the baseline quartiles of fasting insulin, and the predictors of the incidence of MS were analyzed using multivariate regression analysis. RESULTS: Over the follow up period, 8.5% of the cohort developed MS. However, 16.4% of the subjects in the highest quartile of the insulin levels developed MS. In a model that included gender, age, the smoking status, the exercise level, alcohol consumption and the systolic blood pressure, the subjects in the highest quartile of the insulin levels had more than a 5 times greater risk of developing MS compared that of the subjects in the lowest quartile. This predictive importance remained significant even after correcting for all the individual features of MS. CONCLUSIONS: These data suggest that high baseline fasting insulin levels are independent determinants for the future development of MS.

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