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dc.contributor.authorMeikle, PJ
dc.contributor.authorMundra, PA
dc.contributor.authorWong, G
dc.contributor.authorRahman, K
dc.contributor.authorHuynh, K
dc.contributor.authorBarlow, CK
dc.contributor.authorDuly, AMP
dc.contributor.authorHaber, PS
dc.contributor.authorWhitfield, JB
dc.contributor.authorSeth, D
dc.date.accessioned2021-02-04T01:03:49Z
dc.date.available2021-02-04T01:03:49Z
dc.date.issued2015-06-24
dc.identifierpii: PONE-D-14-57194
dc.identifier.citationMeikle, P. J., Mundra, P. A., Wong, G., Rahman, K., Huynh, K., Barlow, C. K., Duly, A. M. P., Haber, P. S., Whitfield, J. B. & Seth, D. (2015). Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment. PLOS ONE, 10 (6), https://doi.org/10.1371/journal.pone.0130346.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/259254
dc.description.abstractLiver disease is the greatest cause of death related to alcohol and a major public health problem. While excessive alcohol intake results in hepatosteatosis in most individuals, this can progress in some to more severe forms of liver disease including fibrosis and cirrhosis. An ongoing challenge in the management of alcoholic liver disease is the identification of liver injury early in the disease process such that intervention strategies can prevent serious long term outcomes. Given that excessive alcohol consumption results in dysregulation of lipid metabolism we applied lipid profiling technology to characterise and compare serum lipid profiles from excessive chronic drinkers with no liver disease to those with advanced alcoholic cirrhosis. In a cohort of 59 excessive drinkers (31 with liver cirrhosis and 28 with no evidence of liver disease) we used electrospray ionisation tandem mass spectrometry to measure over 300 individual lipid species in serum, including species of the major phospholipid, sphingolipid, glycerolipid and sterol classes. Six of the 25 lipid classes and subclasses were significantly associated with alcoholic liver cirrhosis; these included dihexosylceramide, trihexosylceramide, alkylphosphatidylcholine, lysoalkylphosphatidylcholine, phosphatidylinositol and free cholesterol. Multivariate classification models created with only clinical characteristics gave an optimal model with an AUC of 0.847 and an accuracy of 79.7%. The addition of lipid measurements to the clinical characteristics resulted in models of improved performance with an AUC of 0.892 and accuracy of 81.8%. The gain in AUC and accuracy of the combined models highlight the potential of serum lipids as markers of liver injury in alcoholic liver disease.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCirculating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0130346
melbourne.affiliation.departmentBio21
melbourne.affiliation.departmentMelbourne Medical School
melbourne.affiliation.facultyAffiliate
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titlePLoS One
melbourne.source.volume10
melbourne.source.issue6
dc.rights.licenseCC BY
melbourne.elementsid1208048
melbourne.contributor.authorMeikle, Peter
melbourne.contributor.authorHuynh, Kevin
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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