Restoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson's Disease
AuthorTomas, D; Stanic, D; Chua, HK; White, K; Boon, WC; Horne, M
Source TitlePLoS One
PublisherPUBLIC LIBRARY SCIENCE
University of Melbourne Author/sStanic, Davor; Horne, Malcolm; Tomas, Doris; Boon, Wah Chin; CHUA, HUI KHENG
AffiliationFlorey Department of Neuroscience and Mental Health
School of BioSciences
Document TypeJournal Article
CitationsTomas, D., Stanic, D., Chua, H. K., White, K., Boon, W. C. & Horne, M. (2016). Restoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson's Disease. PLOS ONE, 11 (4), https://doi.org/10.1371/journal.pone.0153424.
Access StatusOpen Access
The dyskinesia of Parkinson's Disease is most likely due to excess levels of dopamine in the striatum. The mechanism may be due to aberrant synthesis but also, a deficiency or absence of the Dopamine Transporter. In this study we have examined the proposition that reinstating Dopamine Transporter expression in the striatum would reduce dyskinesia. We transplanted c17.2 cells that stably expressed the Dopamine Transporter into dyskinetic rats. There was a reduction in dyskinesia in rats that received grafts expressing the Dopamine Transporter. Strategies designed to increase Dopamine Transporter in the striatum may be useful in treating the dyskinesia associated with human Parkinson's Disease.
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