Restoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson's Disease

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Tomas, D; Stanic, D; Chua, HK; White, K; Boon, WC; Horne, MDate
2016-04-14Source Title
PLoS OnePublisher
PUBLIC LIBRARY SCIENCEUniversity of Melbourne Author/s
Stanic, Davor; Horne, Malcolm; Tomas, Doris; Boon, Wah Chin; CHUA, HUI KHENGAffiliation
Florey Department of Neuroscience and Mental HealthSchool of BioSciences
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Tomas, D., Stanic, D., Chua, H. K., White, K., Boon, W. C. & Horne, M. (2016). Restoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson's Disease. PLOS ONE, 11 (4), https://doi.org/10.1371/journal.pone.0153424.Access Status
Open AccessAbstract
The dyskinesia of Parkinson's Disease is most likely due to excess levels of dopamine in the striatum. The mechanism may be due to aberrant synthesis but also, a deficiency or absence of the Dopamine Transporter. In this study we have examined the proposition that reinstating Dopamine Transporter expression in the striatum would reduce dyskinesia. We transplanted c17.2 cells that stably expressed the Dopamine Transporter into dyskinetic rats. There was a reduction in dyskinesia in rats that received grafts expressing the Dopamine Transporter. Strategies designed to increase Dopamine Transporter in the striatum may be useful in treating the dyskinesia associated with human Parkinson's Disease.
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