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dc.contributor.authorTomas, D
dc.contributor.authorStanic, D
dc.contributor.authorChua, HK
dc.contributor.authorWhite, K
dc.contributor.authorBoon, WC
dc.contributor.authorHorne, M
dc.date.accessioned2021-02-04T01:10:20Z
dc.date.available2021-02-04T01:10:20Z
dc.date.issued2016-04-14
dc.identifierpii: PONE-D-15-42661
dc.identifier.citationTomas, D., Stanic, D., Chua, H. K., White, K., Boon, W. C. & Horne, M. (2016). Restoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson's Disease. PLOS ONE, 11 (4), https://doi.org/10.1371/journal.pone.0153424.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/259282
dc.description.abstractThe dyskinesia of Parkinson's Disease is most likely due to excess levels of dopamine in the striatum. The mechanism may be due to aberrant synthesis but also, a deficiency or absence of the Dopamine Transporter. In this study we have examined the proposition that reinstating Dopamine Transporter expression in the striatum would reduce dyskinesia. We transplanted c17.2 cells that stably expressed the Dopamine Transporter into dyskinetic rats. There was a reduction in dyskinesia in rats that received grafts expressing the Dopamine Transporter. Strategies designed to increase Dopamine Transporter in the striatum may be useful in treating the dyskinesia associated with human Parkinson's Disease.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleRestoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson's Disease
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0153424
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentSchool of BioSciences
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.affiliation.facultyScience
melbourne.source.titlePLoS One
melbourne.source.volume11
melbourne.source.issue4
dc.rights.licenseCC BY
melbourne.elementsid1055967
melbourne.contributor.authorStanic, Davor
melbourne.contributor.authorHorne, Malcolm
melbourne.contributor.authorTomas, Doris
melbourne.contributor.authorBoon, Wah Chin
melbourne.contributor.authorCHUA, HUI KHENG
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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