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dc.contributor.authorRios, AC
dc.contributor.authorFu, NY
dc.contributor.authorJamieson, PR
dc.contributor.authorPal, B
dc.contributor.authorWhitehead, L
dc.contributor.authorNicholas, KR
dc.contributor.authorLindeman, GJ
dc.contributor.authorVisvader, JE
dc.date.accessioned2021-02-04T01:10:33Z
dc.date.available2021-02-04T01:10:33Z
dc.date.issued2016-04-01
dc.identifierpii: ncomms11400
dc.identifier.citationRios, A. C., Fu, N. Y., Jamieson, P. R., Pal, B., Whitehead, L., Nicholas, K. R., Lindeman, G. J. & Visvader, J. E. (2016). Essential role for a novel population of binucleated mammary epithelial cells in lactation. NATURE COMMUNICATIONS, 7 (1), https://doi.org/10.1038/ncomms11400.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/259283
dc.description.abstractThe mammary gland represents a unique tissue to study organogenesis as it predominantly develops in the post-natal animal and undergoes dramatic morphogenetic changes during puberty and the reproductive cycle. The physiological function of the mammary gland is to produce milk to sustain the newborn. Here we view the lactating gland through three-dimensional confocal imaging of intact tissue. We observed that the majority of secretory alveolar cells are binucleated. These cells first arise in very late pregnancy due to failure of cytokinesis and are larger than mononucleated cells. Augmented expression of Aurora kinase-A and Polo-like kinase-1 at the lactogenic switch likely mediates the formation of binucleated cells. Our findings demonstrate an important physiological role for polyploid mammary epithelial cells in lactation, and based on their presence in five different species, suggest that binucleated cells evolved to maximize milk production and promote the survival of offspring across all mammalian species.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEssential role for a novel population of binucleated mammary epithelial cells in lactation
dc.typeJournal Article
dc.identifier.doi10.1038/ncomms11400
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleNature Communications
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1055969
melbourne.contributor.authorFu, Nai
melbourne.contributor.authorWhitehead, Lachlan
melbourne.contributor.authorPal, Bhupinder
melbourne.contributor.authorLindeman, Geoffrey
melbourne.contributor.authorRios, Anne
melbourne.contributor.authorVisvader, Jane
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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