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    Metabolomics in epidemiology: from metabolite concentrations to integrative reaction networks

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    Author
    Fearnley, LG; Inouye, M
    Date
    2016-10-01
    Source Title
    International Journal of Epidemiology
    Publisher
    OXFORD UNIV PRESS
    University of Melbourne Author/s
    Inouye, Michael; Fearnley, Liam
    Affiliation
    Clinical Pathology
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Fearnley, L. G. & Inouye, M. (2016). Metabolomics in epidemiology: from metabolite concentrations to integrative reaction networks. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 45 (5), pp.1319-1328. https://doi.org/10.1093/ije/dyw046.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259284
    DOI
    10.1093/ije/dyw046
    NHMRC Grant code
    NHMRC/1061435
    NHMRC/1062227
    Abstract
    Metabolomics is becoming feasible for population-scale studies of human disease. In this review, we survey epidemiological studies that leverage metabolomics and multi-omics to gain insight into disease mechanisms. We outline key practical, technological and analytical limitations while also highlighting recent successes in integrating these data. The use of multi-omics to infer reaction rates is discussed as a potential future direction for metabolomics research, as a means of identifying biomarkers as well as inferring causality. Furthermore, we highlight established analysis approaches as well as simulation-based methods currently used in single- and multi-cell levels in systems biology.

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