University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Surgery (St Vincent's)
  • Surgery (St Vincent's) - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Surgery (St Vincent's)
  • Surgery (St Vincent's) - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Minimal residual disease in breast cancer: an overview of circulating and disseminated tumour cells

    Thumbnail
    Download
    Published version (1.057Mb)

    Citations
    Scopus
    Altmetric
    14
    Author
    Tachtsidis, A; McInnes, LM; Jacobsen, N; Thompson, EW; Saunders, CM
    Date
    2016-08-01
    Source Title
    Clinical and Experimental Metastasis
    Publisher
    SPRINGER
    University of Melbourne Author/s
    Thompson, Erik
    Affiliation
    Surgery (St Vincent's)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Tachtsidis, A., McInnes, L. M., Jacobsen, N., Thompson, E. W. & Saunders, C. M. (2016). Minimal residual disease in breast cancer: an overview of circulating and disseminated tumour cells. CLINICAL & EXPERIMENTAL METASTASIS, 33 (6), pp.521-550. https://doi.org/10.1007/s10585-016-9796-8.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259294
    DOI
    10.1007/s10585-016-9796-8
    NHMRC Grant code
    NHMRC/1027527
    NHMRC/1083172
    Abstract
    Within the field of cancer research, focus on the study of minimal residual disease (MRD) in the context of carcinoma has grown exponentially over the past several years. MRD encompasses circulating tumour cells (CTCs)-cancer cells on the move via the circulatory or lymphatic system, disseminated tumour cells (DTCs)-cancer cells which have escaped into a distant site (most studies have focused on bone marrow), and resistant cancer cells surviving therapy-be they local or distant, all of which may ultimately give rise to local relapse or overt metastasis. Initial studies simply recorded the presence and number of CTCs and DTCs; however recent advances are allowing assessment of the relationship between their persistence, patient prognosis and the biological properties of MRD, leading to a better understanding of the metastatic process. Technological developments for the isolation and analysis of circulating and disseminated tumour cells continue to emerge, creating new opportunities to monitor disease progression and perhaps alter disease outcome. This review outlines our knowledge to date on both measurement and categorisation of MRD in the form of CTCs and DTCs with respect to how this relates to cancer outcomes, and the hurdles and future of research into both CTCs and DTCs.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [52609]
    • Surgery (St Vincent's) - Research Publications [431]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors