The life history of neochromosomes revealed
AuthorPapenfuss, AT; Thomas, DM
Source TitleMolecular & cellular oncology
PublisherTAYLOR & FRANCIS INC
AffiliationMedical Biology (W.E.H.I.)
Sir Peter MacCallum Department of Oncology
Document TypeJournal Article
CitationsPapenfuss, A. T. & Thomas, D. M. (2015). The life history of neochromosomes revealed. MOLECULAR & CELLULAR ONCOLOGY, 2 (4), https://doi.org/10.1080/23723556.2014.1000698.
Access StatusOpen Access
Neochromosomes are a little-studied class of chromosome-scale mutations that drive some cancers. By sequencing isolated neochromosomes from liposarcomas, we recently defined their structure at single-nucleotide resolution and proposed a model for their life history. Here, we summarize that work, highlighting significant aspects and providing historical context and insight into the discovery process.
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