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dc.contributor.authorHannan, NJ
dc.contributor.authorBrownfoot, FC
dc.contributor.authorCannon, P
dc.contributor.authorDeo, M
dc.contributor.authorBeard, S
dc.contributor.authorNguyen, TV
dc.contributor.authorPalmer, KR
dc.contributor.authorTong, S
dc.contributor.authorKaitu'u-Lino, TJ
dc.date.accessioned2021-02-04T01:21:46Z
dc.date.available2021-02-04T01:21:46Z
dc.date.issued2017-05-12
dc.identifierpii: 10.1038/s41598-017-01993-w
dc.identifier.citationHannan, N. J., Brownfoot, F. C., Cannon, P., Deo, M., Beard, S., Nguyen, T. V., Palmer, K. R., Tong, S. & Kaitu'u-Lino, T. J. (2017). Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-01993-w.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/259337
dc.description.abstractPreeclampsia is a disease of pregnancy associated with placental oxidative stress, inflammation and elevated release of anti-angiogenic factors sFlt-1 and soluble endoglin. These placental factors cause generalized maternal endothelial dysfunction. There are no treatments to halt disease progression; delivery is the only cure. Resveratrol modulates pathways involved in inflammation and oxidative stress and may offer a potential therapeutic for preeclampsia. Resveratrol reduced sFlt-1, sFlt-1 e15a and soluble endoglin secretion from primary trophoblasts and HUVECs and reduced mRNA expression of pro-inflammatory molecules NFκB, IL-6 and IL-1β in trophoblasts. IL-6, IL-1β and TNFα secretion were also significantly reduced. In HUVECs, resveratrol significantly increased mRNA of anti-oxidant enzymes HO-1, NQO1, GCLC and TXN but did not significantly alter HO-1 protein expression, whilst reducing HO-1 protein in trophoblast. Endothelial dysfunction was induced in HUVECs using TNFα, increasing expression of cell adhesion molecule VCAM1 and adhesion of peripheral blood mononuclear cells, both of which were increased further by resveratrol. In contrast, resveratrol significantly reduced TNFα-induced Endothelin-1 (a vasoconstrictor) and significantly increased the phosphorylation of endothelial nitric oxide synthase (eNOS). In summary, resveratrol decreases secretion of anti-angiogenic factors however its effects on the endothelium are mixed. Overall, it may have potential as a treatment for preeclampsia.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleResveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-017-01993-w
melbourne.affiliation.departmentObstetrics and Gynaecology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
melbourne.identifier.nhmrc1062418
melbourne.identifier.nhmrc1050765
dc.rights.licenseCC BY
melbourne.elementsid1210057
melbourne.contributor.authorCannon, Ping
melbourne.contributor.authorLino, Tu'uhevaha
melbourne.contributor.authorTong, Stephen
melbourne.contributor.authorBrownfoot, Fiona
melbourne.contributor.authorHannan, Natalie
melbourne.contributor.authorPalmer, Kirsten
melbourne.contributor.authorBeard, Sally
melbourne.contributor.authorNguyen, Tuong-Vi
dc.identifier.eissn2045-2322
melbourne.identifier.fundernameidNHMRC, 1062418
melbourne.identifier.fundernameidNHMRC, 1050765
melbourne.accessrightsOpen Access


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