A Label-Free, Quantitative Fecal Hemoglobin Detection Platform for Colorectal Cancer Screening
AuthorSoraya, GV; Nguyen, TC; Abeyrathne, CD; Huynh, DH; Chan, J; Nguyen, PD; Nasr, B; Chana, G; Kwan, P; Skafidas, E
University of Melbourne Author/sNasr, Babak; Soraya, Gita; Abeyrathne, Chathurika; Huynh, Duc Hau; Chan, Jianxiong; Nguyen, Phuong; Chana, Gursharan; Kwan, Patrick; Skafidas, Efstratios; Nguyen, Thanh
AffiliationElectrical and Electronic Engineering
Medicine and Radiology
Document TypeJournal Article
CitationsSoraya, G. V., Nguyen, T. C., Abeyrathne, C. D., Huynh, D. H., Chan, J., Nguyen, P. D., Nasr, B., Chana, G., Kwan, P. & Skafidas, E. (2017). A Label-Free, Quantitative Fecal Hemoglobin Detection Platform for Colorectal Cancer Screening. BIOSENSORS-BASEL, 7 (2), https://doi.org/10.3390/bios7020019.
Access StatusOpen Access
ARC Grant codeARC/DP140101967
The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource settings. The label-free prototype has a lower limit of detection (LOD) of 10 µg hemoglobin per gram (Hb/g) of feces, comparable to that of conventional laboratory based quantitative FIT diagnostic systems.
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