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    Dexamethasone inhibits IL-9 production by human T cells.

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    12
    Author
    Holz, LE; Jakobsen, KP; Van Snick, J; Cormont, F; Sewell, WA
    Date
    2005
    Source Title
    Journal of Inflammation
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Holz, Lauren
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Holz, L. E., Jakobsen, K. P., Van Snick, J., Cormont, F. & Sewell, W. A. (2005). Dexamethasone inhibits IL-9 production by human T cells.. J Inflamm (Lond), 2 (1), pp.3-. https://doi.org/10.1186/1476-9255-2-3.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259378
    DOI
    10.1186/1476-9255-2-3
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1112611
    Abstract
    BACKGROUND: Interleukin 9 (IL-9) is produced by activated CD4+ T cells. Its effects include stimulation of mucus production, enhanced mast cell proliferation, enhanced eosinophil function, and IgE production. These effects are consistent with a role in allergic diseases. Glucocorticoids have potent anti-inflammatory effects, including suppression of cytokine synthesis, and are widely used in the treatment of allergic conditions. METHODS: We examined the effect of the glucocorticoid dexamethasone (Dex) on IL-9 mRNA expression and protein secretion with real-time RT-PCR and ELISA. Peripheral blood mononuclear cells (PBMC) were prepared from human volunteers and activated with OKT3. CD4+ T cells were purified from PBMC and activated with OKT3 plus PMA. RESULTS: IL-9 mRNA abundance and protein secretion were both markedly reduced following treatment of activated PBMC with Dex. mRNA levels were reduced to 0.7% of control values and protein secretion was reduced to 2.8% of controls. In CD4+ T cells, Dex reduced protein secretion to a similar extent. The IC50 value of Dex on mRNA expression was 4 nM. CONCLUSION: These results indicate that IL-9 production is very markedly inhibited by Dex. The findings raise the possibility that the beneficial effects of glucocorticoids in the treatment of allergic diseases are in part mediated by inhibition of IL-9 production.

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