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dc.contributor.authorWan, W
dc.contributor.authorCao, L
dc.contributor.authorKhanabdali, R
dc.contributor.authorKalionis, B
dc.contributor.authorTai, X
dc.contributor.authorXia, S
dc.date.accessioned2021-02-04T01:30:19Z
dc.date.available2021-02-04T01:30:19Z
dc.date.issued2016-01-01
dc.identifier.citationWan, W., Cao, L., Khanabdali, R., Kalionis, B., Tai, X. & Xia, S. (2016). The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation. JOURNAL OF IMMUNOLOGY RESEARCH, 2016, https://doi.org/10.1155/2016/6430423.
dc.identifier.issn2314-8861
dc.identifier.urihttp://hdl.handle.net/11343/259384
dc.description.abstractNeuropathic pain (NPP) is intolerable, persistent, and specific type of long-term pain. It is considered to be a direct consequence of pathological changes affecting the somatosensory system and can be debilitating for affected patients. Despite recent progress and growing interest in understanding the pathogenesis of the disease, NPP still presents a major diagnostic and therapeutic challenge. High mobility group box 1 (HMGB1) mediates inflammatory and immune reactions in nervous system and emerging evidence reveals that HMGB1 plays an essential role in neuroinflammation through receptors such as Toll-like receptors (TLR), receptor for advanced glycation end products (RAGE), C-X-X motif chemokines receptor 4 (CXCR4), and N-methyl-D-aspartate (NMDA) receptor. In this review, we present evidence from studies that address the role of HMGB1 in NPP. First, we review studies aimed at determining the role of HMGB1 in NPP and discuss the possible mechanisms underlying HMGB1-mediated NPP progression where receptors for HMGB1 are involved. Then we review studies that address HMGB1 as a potential therapeutic target for NPP.
dc.languageEnglish
dc.publisherHINDAWI LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation
dc.typeJournal Article
dc.identifier.doi10.1155/2016/6430423
melbourne.affiliation.departmentObstetrics and Gynaecology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleJournal of Immunology Research
melbourne.source.volume2016
dc.rights.licenseCC BY
melbourne.elementsid1069894
melbourne.contributor.authorKalionis, Bill
melbourne.contributor.authorKhanabdali, Ramin
dc.identifier.eissn2314-7156
melbourne.accessrightsOpen Access


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