Tumor-infiltrating lymphocytes, breast cancer subtypes and therapeutic efficacy
University of Melbourne Author/sLoi, Sherene
AffiliationSir Peter MacCallum Department of Oncology
Document TypeJournal Article
CitationsLoi, S. (2013). Tumor-infiltrating lymphocytes, breast cancer subtypes and therapeutic efficacy. ONCOIMMUNOLOGY, 2 (7), https://doi.org/10.4161/onci.24720.
Access StatusOpen Access
By analyzing over 2000 samples from a randomized clinical trial, we have recently associated high levels of tumor-infiltrating lymphocytes with an excellent prognosis among triple negative breast cancer patients as well with improved clinical responses to immunogenic chemotherapy among patients bearing HER2 over-expression. These findings suggest that immunomodulation could represent a new approach to treat these aggressive breast cancer subtypes.
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