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dc.contributor.authorIbbott, GS
dc.contributor.authorHaworth, A
dc.contributor.authorFollowill, DS
dc.date.accessioned2021-02-04T01:32:06Z
dc.date.available2021-02-04T01:32:06Z
dc.date.issued2013-12-19
dc.identifier.citationIbbott, G. S., Haworth, A. & Followill, D. S. (2013). Quality assurance for clinical trials.. Front Oncol, 3, pp.311-. https://doi.org/10.3389/fonc.2013.00311.
dc.identifier.issn2234-943X
dc.identifier.urihttp://hdl.handle.net/11343/259393
dc.description.abstractCooperative groups, of which the Radiation Therapy Oncology Group is one example, conduct national clinical trials that often involve the use of radiation therapy. In preparation for such a trial, the cooperative group prepares a protocol to define the goals of the trial, the rationale for its design, and the details of the treatment procedure to be followed. The Radiological Physics Center (RPC) is one of several quality assurance (QA) offices that is charged with assuring that participating institutions deliver doses that are clinically consistent and comparable. The RPC does this by conducting a variety of independent audits and credentialing processes. The RPC has compiled data showing that credentialing can help institutions comply with the requirements of a cooperative group clinical protocol. Phantom irradiations have been demonstrated to exercise an institution's procedures for planning and delivering advanced external beam techniques (1-3). Similarly, RPC data indicate that a rapid review of patient treatment records or planning procedures can improve compliance with clinical trials (4). The experiences of the RPC are presented as examples of the contributions that a national clinical trials QA center can make to cooperative group trials. These experiences illustrate the critical need for comprehensive QA to assure that clinical trials are successful and cost-effective. The RPC is supported by grants CA 10953 and CA 81647 from the National Cancer Institute, NIH, DHHS.
dc.languageeng
dc.publisherFrontiers Media SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleQuality assurance for clinical trials.
dc.typeJournal Article
dc.identifier.doi10.3389/fonc.2013.00311
melbourne.affiliation.departmentClinical Pathology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFrontiers in Oncology
melbourne.source.volume3
melbourne.source.pages311-
dc.rights.licenseCC BY
melbourne.elementsid1070912
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867736
melbourne.contributor.authorHaworth, Annette
dc.identifier.eissn2234-943X
melbourne.accessrightsOpen Access


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