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    Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain

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    Author
    Perrin, A; Larsonneur, E; Nicholson, AC; Edwards, DJ; Gundlach, KM; Whitney, AM; Gulvik, CA; Bell, ME; Rendueles, O; Cury, J; ...
    Date
    2017-05-24
    Source Title
    Nature Communications
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Edwards, David; Holt, Kathryn
    Affiliation
    Biochemistry and Molecular Biology
    Metadata
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    Document Type
    Journal Article
    Citations
    Perrin, A., Larsonneur, E., Nicholson, A. C., Edwards, D. J., Gundlach, K. M., Whitney, A. M., Gulvik, C. A., Bell, M. E., Rendueles, O., Cury, J., Hugon, P., Clermont, D., Enouf, V., Loparev, V., Juieng, P., Monson, T., Warshauer, D., Elbadawi, L. I., Walters, M. S. ,... Brisse, S. (2017). Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain. NATURE COMMUNICATIONS, 8 (1), https://doi.org/10.1038/ncomms15483.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259402
    DOI
    10.1038/ncomms15483
    Abstract
    An atypically large outbreak of Elizabethkingia anophelis infections occurred in Wisconsin. Here we show that it was caused by a single strain with thirteen characteristic genomic regions. Strikingly, the outbreak isolates show an accelerated evolutionary rate and an atypical mutational spectrum. Six phylogenetic sub-clusters with distinctive temporal and geographic dynamics are revealed, and their last common ancestor existed approximately one year before the first recognized human infection. Unlike other E. anophelis, the outbreak strain had a disrupted DNA repair mutY gene caused by insertion of an integrative and conjugative element. This genomic change probably contributed to the high evolutionary rate of the outbreak strain and may have increased its adaptability, as many mutations in protein-coding genes occurred during the outbreak. This unique discovery of an outbreak caused by a naturally occurring mutator bacterial pathogen provides a dramatic example of the potential impact of pathogen evolutionary dynamics on infectious disease epidemiology.

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