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dc.contributor.authorDongworth, RK
dc.contributor.authorCampbell-Washburn, AE
dc.contributor.authorCabrera-Fuentes, HA
dc.contributor.authorBulluck, H
dc.contributor.authorRoberts, T
dc.contributor.authorPrice, AN
dc.contributor.authorHernandez-Resendiz, S
dc.contributor.authorOrdidge, RJ
dc.contributor.authorThomas, DL
dc.contributor.authorYellon, DM
dc.contributor.authorLythgoe, MF
dc.contributor.authorHausenloy, DJ
dc.date.accessioned2021-02-04T01:34:02Z
dc.date.available2021-02-04T01:34:02Z
dc.date.issued2017-05-23
dc.identifierpii: 10.1038/s41598-017-02544-z
dc.identifier.citationDongworth, R. K., Campbell-Washburn, A. E., Cabrera-Fuentes, H. A., Bulluck, H., Roberts, T., Price, A. N., Hernandez-Resendiz, S., Ordidge, R. J., Thomas, D. L., Yellon, D. M., Lythgoe, M. F. & Hausenloy, D. J. (2017). Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-02544-z.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/259404
dc.description.abstractT2-weighted cardiovascular magnetic resonance (T2-CMR) of myocardial edema can quantify the area-at-risk (AAR) following acute myocardial infarction (AMI), and has been used to assess myocardial salvage by new cardioprotective therapies. However, some of these therapies may reduce edema, leading to an underestimation of the AAR by T2-CMR. Here, we investigated arterial spin labeling (ASL) perfusion CMR as a novel approach to quantify the AAR following AMI. Adult B6sv129-mice were subjected to in vivo left coronary artery ligation for 30 minutes followed by 72 hours reperfusion. T2-mapping was used to quantify the edema-based AAR (% of left ventricle) following ischemic preconditioning (IPC) or cyclosporin-A (CsA) treatment. In control animals, the AAR by T2-mapping corresponded to that delineated by histology. As expected, both IPC and CsA reduced MI size. However, IPC, but not CsA, also reduced myocardial edema leading to an underestimation of the AAR by T2-mapping. In contrast, regions of reduced myocardial perfusion delineated by cardiac ASL were able to delineate the AAR when compared to both T2-mapping and histology in control animals, and were not affected by either IPC or CsA. Therefore, ASL perfusion CMR may be an alternative method for quantifying the AAR following AMI, which unlike T2-mapping, is not affected by IPC.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleQuantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-017-02544-z
melbourne.affiliation.departmentRadiology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleScientific Reports
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1213681
melbourne.contributor.authorOrdidge, Roger
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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