Show simple item record

dc.contributor.authorEmdin, CA
dc.contributor.authorAnderson, SG
dc.contributor.authorSalimi-Khorshidi, G
dc.contributor.authorWoodward, M
dc.contributor.authorMacMahon, S
dc.contributor.authorDwyer, T
dc.contributor.authorRahimi, K
dc.date.accessioned2021-02-04T01:39:45Z
dc.date.available2021-02-04T01:39:45Z
dc.date.issued2017-02-01
dc.identifierpii: dyw053
dc.identifier.citationEmdin, C. A., Anderson, S. G., Salimi-Khorshidi, G., Woodward, M., MacMahon, S., Dwyer, T. & Rahimi, K. (2017). Usual blood pressure, atrial fibrillation and vascular risk: evidence from 4.3 million adults.. Int J Epidemiol, 46 (1), pp.162-172. https://doi.org/10.1093/ije/dyw053.
dc.identifier.issn0300-5771
dc.identifier.urihttp://hdl.handle.net/11343/259436
dc.description.abstractBackground: Although elevated blood pressure is associated with an increased risk of atrial fibrillation (AF), it is unclear if this association varies by individual characteristics. Furthermore, the associations between AF and a range of different vascular events are yet to be reliably quantified. Methods: Using linked electronic health records, we examined the time to first diagnosis of AF and time to first diagnosis of nine vascular events in a cohort of 4.3 million adults, aged 30 to 90 years, in the UK. Results: : A 20-mmHg higher usual systolic blood pressure was associated with a higher risk of AF [hazard ratio (HR) 1.21, 95% confidence interval (CI) 1.19, 1.22]. The strength of the association declined with increasing age, from an HR of 1.91 (CI 1.75, 2.09) at age 30-40 to an HR of 1.01 (CI 0.97, 1.04) at age 80-90 years. AF without antithrombotic use at baseline was associated with a greater risk of any vascular event than AF with antithrombotic usage ( P interaction < 0.0001). AF without baseline antithrombotic usage was associated with an increased risk of ischaemic heart disease (HR 2.52, CI 2.23, 2.84), heart failure (HR 3.80, CI 3.50, 4.12), ischaemic stroke (HR 2.72, CI 2.19, 3.38), unspecified stroke (HR 2.59, CI 2.25, 2.99), haemorrhagic stroke, chronic kidney disease, peripheral arterial disease and vascular dementia, but not aortic aneurysm. Conclusions: The association between elevated blood pressure and AF attenuates with increasing age. AF without antithrombotic usage is associated with an increased risk of eight vascular events.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleUsual blood pressure, atrial fibrillation and vascular risk: evidence from 4.3 million adults.
dc.typeJournal Article
dc.identifier.doi10.1093/ije/dyw053
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleInternational Journal of Epidemiology
melbourne.source.volume46
melbourne.source.issue1
melbourne.source.pages162-172
dc.rights.licenseCC BY
melbourne.elementsid1214648
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407172
melbourne.contributor.authorDwyer, Terence
dc.identifier.eissn1464-3685
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record