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dc.contributor.authorDicken, AJ
dc.contributor.authorEvans, JPO
dc.contributor.authorRogers, KD
dc.contributor.authorStone, N
dc.contributor.authorGreenwood, C
dc.contributor.authorGodber, SX
dc.contributor.authorClement, JG
dc.contributor.authorLyburn, ID
dc.contributor.authorMartin, RM
dc.contributor.authorZioupos, P
dc.date.accessioned2021-02-04T01:49:53Z
dc.date.available2021-02-04T01:49:53Z
dc.date.issued2016-07-01
dc.identifierpii: srep29011
dc.identifier.citationDicken, A. J., Evans, J. P. O., Rogers, K. D., Stone, N., Greenwood, C., Godber, S. X., Clement, J. G., Lyburn, I. D., Martin, R. M. & Zioupos, P. (2016). Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter. SCIENTIFIC REPORTS, 6 (1), https://doi.org/10.1038/srep29011.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/259489
dc.description.abstractOsteoporotic fractures present a significant social and economic burden, which is set to rise commensurately with the aging population. Greater understanding of the physicochemical differences between osteoporotic and normal conditions will facilitate the development of diagnostic technologies with increased performance and treatments with increased efficacy. Using coherent X-ray scattering we have evaluated a population of 108 ex vivo human bone samples comprised of non-fracture and fracture groups. Principal component fed linear discriminant analysis was used to develop a classification model to discern each condition resulting in a sensitivity and specificity of 93% and 91%, respectively. Evaluating the coherent X-ray scatter differences from each condition supports the hypothesis that a causal physicochemical change has occurred in the fracture group. This work is a critical step along the path towards developing an in vivo diagnostic tool for fracture risk prediction.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleClassification of fracture and non-fracture groups by analysis of coherent X-ray scatter
dc.typeJournal Article
dc.identifier.doi10.1038/srep29011
melbourne.affiliation.departmentMelbourne Dental School
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleScientific Reports
melbourne.source.volume6
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1078631
melbourne.contributor.authorClement, John
dc.identifier.eissn2045-2322
melbourne.accessrightsOpen Access


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