Show simple item record

dc.contributor.authorMaloy, KJ
dc.contributor.authorSalaun, L
dc.contributor.authorCahill, R
dc.contributor.authorDougan, G
dc.contributor.authorSaunders, NJ
dc.contributor.authorPowrie, F
dc.date.accessioned2021-02-04T01:52:26Z
dc.date.available2021-02-04T01:52:26Z
dc.date.issued2003-01-06
dc.identifier.citationMaloy, K. J., Salaun, L., Cahill, R., Dougan, G., Saunders, N. J. & Powrie, F. (2003). CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.. J Exp Med, 197 (1), pp.111-119. https://doi.org/10.1084/jem.20021345.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/259503
dc.description.abstractCD4(+)CD25(+) regulatory T (T(R)) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell-reconstituted recombination-activating gene (RAG)(-/-) mice as a model to study the ability of CD4(+)CD25(+) T(R) cells to inhibit bacterially triggered intestinal inflammation. H. hepaticus infection elicited both T cell-mediated and T cell-independent intestinal inflammation, both of which were inhibited by adoptively transferred CD4(+)CD25(+) T(R) cells. T cell-independent pathology was accompanied by activation of the innate immune system that was also inhibited by CD4(+)CD25(+) T(R) cells. Suppression of innate immune pathology was dependent on T cell-derived interleukin 10 and also on the production of transforming growth factor beta. Thus, CD4(+)CD25(+) T(R) cells do not only suppress adaptive T cell responses, but are also able to control pathology mediated by innate immune mechanisms.
dc.languageeng
dc.publisherRockefeller University Press
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleCD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.
dc.typeJournal Article
dc.identifier.doi10.1084/jem.20021345
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume197
melbourne.source.issue1
melbourne.source.pages111-119
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1080856
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193798
melbourne.contributor.authorDougan, Gordon
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record