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    Targeting of a Transporter to the Outer Apicoplast Membrane in the Human Malaria Parasite Plasmodium falciparum

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    12
    Author
    Lim, L; Sayers, CP; Goodman, CD; McFadden, GI
    Date
    2016-07-21
    Source Title
    PLoS One
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Goodman, Christopher; Sayers, Claire; McFadden, Geoffrey; LIM, LITING
    Affiliation
    School of BioSciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Lim, L., Sayers, C. P., Goodman, C. D. & McFadden, G. I. (2016). Targeting of a Transporter to the Outer Apicoplast Membrane in the Human Malaria Parasite Plasmodium falciparum. PLOS ONE, 11 (7), https://doi.org/10.1371/journal.pone.0159603.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/259509
    DOI
    10.1371/journal.pone.0159603
    ARC Grant code
    ARC/DP130103236
    Abstract
    Apicoplasts are vestigial plastids in apicomplexan parasites like Plasmodium, the causative agent of malaria. Apicomplexan parasites are dependant on their apicoplasts for synthesis of various molecules that they are unable to scavenge in sufficient quantity from their host, which makes apicoplasts attractive drug targets. Proteins known as plastid phosphate translocators (pPTs) are embedded in the outer apicoplast membrane and are responsible for the import of carbon, energy and reducing power to drive anabolic synthesis in the organelle. We investigated how a pPT is targeted into the outer apicoplast membrane of the human malaria parasite P. falciparum. We showed that a transmembrane domain is likely to act as a recessed signal anchor to direct the protein into the endomembrane system, and that a tyrosine in the cytosolic N-terminus of the protein is essential for targeting, but one or more, as yet unidentified, factors are also essential to direct the protein into the outer apicoplast membrane.

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